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AB242871

Anti-CXCL7/PBP antibody [EPR19780-67] - BSA and Azide free (Detector)

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Rabbit Recombinant Monoclonal CXCL7/PBP antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

대체 명칭 보기

CTAP3, CXCL7, SCYB7, TGB1, THBGB1, PPBP, Platelet basic protein, PBP, C-X-C motif chemokine 7, Leukocyte-derived growth factor, Macrophage-derived growth factor, Small-inducible cytokine B7, LDGF, MDGF

1 이미지
Sandwich ELISA - Anti-CXCL7/PBP antibody [EPR19780-67] - BSA and Azide free (Detector) (AB242871)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-CXCL7/PBP antibody [EPR19780-67] - BSA and Azide free (Detector) (AB242871)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab216171).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR19780-67

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB216171

Human CXCL7 / PBP ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CXCL7 / PBP ELISA Kit (AB216171)

  • 4
  • 2
Primary Antibodies

AB282250

Anti-Protein S antibody [EPR24509-155] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-Protein S antibody [EPR24509-155] - BSA and Azide free (Capture) (AB282250)

  • 0
  • 0
Primary Antibodies

AB285156

Anti-Placental alkaline phosphatase (PLAP) antibody [EPR23631-234] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Placental alkaline phosphatase (PLAP) antibody [EPR23631-234] - BSA and Azide free (Detector) (AB285156)

  • 0
  • 0
Primary Antibodies

AB288722

Anti-DRP1 antibody [EPR24461-48] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-DRP1 antibody [EPR24461-48] - BSA and Azide free (Capture) (AB288722)

  • 0
  • 0
Primary Antibodies

AB288745

Anti-NFkB p100/NFKB2 antibody [YCA-R23655-22 H1L4] - BSA and Azide free (Capture)

Recombinant

Sandwich ELISA - Anti-NFkB p100/NFKB2 antibody [YCA-R23655-22 H1L4] - BSA and Azide free (Capture) (AB288745)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab242871 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human CXCL7. The recommended pair for sandwich ELISA is:
Capture: ab242626, Human CXCL7 Capture Antibody (unconjugated)
Detector: ab242871, Human CXCL7 Detector Antibody (unconjugated)
The reference range value is 3.9 - 250 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The target CXCL7 also known as PBP PBP-172 or PPBP is a chemokine with a molecular mass of around 11 kDa. It is a platelet basic protein (PBP) belonging to the family of CXC chemokines. This protein is extensively expressed in megakaryocytes and stored in the alpha-granules of platelets. Upon platelet activation CXCL7 is released and becomes a potent attractant and activator of neutrophils. It travels through the bloodstream and impacts extracellular signaling processes.
Biological function summary

The chemokine plays a significant role in the regulation of inflammation. CXCL7 is not only an individual entity but can form complexes with glycosaminoglycans on cell surfaces enhancing its functionality. This interaction helps in modulating immune responses by recruiting neutrophils and monocytes to sites of injury or infection. The chemokine contributes to wound healing and tissue repair through its involvement in the inflammatory phase.

Pathways

CXCL7 is involved in the chemokine signaling pathway and is an important mediator in the immune system's response to infections. It is related to other chemokine family proteins like CXCL8 (IL-8) which share similar pathways in inflammatory responses. These proteins interact with specific receptors on leukocytes inducing changes in the cytoskeleton and promoting chemotaxis which is the directed movement towards chemical stimuli.

CXCL7 is associated with various inflammatory conditions and has been implicated in atherosclerosis and rheumatoid arthritis. In these conditions elevated levels of this chemokine correlate with increased recruitment and activation of neutrophils exacerbating inflammation. CXCL7 also shares interactions with other proteins such as CXCL1 affecting the progression and severity of these disorders. The understanding of CXCL7's role in such pathologies offers potential therapeutic avenues for intervention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation.
See full target information PPBP
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Product promise

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