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AB236612

Anti-CYB5B antibody

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Rabbit Polyclonal CYB5B antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CYB5B aa 1 to C-terminus.

대체 명칭 보기

CYB5M, OMB5, CYB5B, Cytochrome b5 type B, Cytochrome b5 outer mitochondrial membrane isoform

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYB5B antibody (AB236612)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYB5B antibody (AB236612)

Paraffin-embedded human kidney tissue stained for CYB5B using ab236612 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-CYB5B antibody (AB236612)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CYB5B antibody (AB236612)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for CYB5B (green) using ab236612 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-congugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CYB5B aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O43169

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보완 제품

Primary Antibodies

AB237813

Anti-CYB5R2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYB5R2 antibody (AB237813)

  • 0
  • 0
Primary Antibodies

AB236608

Anti-APH antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-APH antibody (AB236608)

  • 0
  • 0
Primary Antibodies

AB233127

Anti-MSS1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MSS1 antibody (AB233127)

  • 0
  • 0
Primary Antibodies

AB154804

Anti-PFKM antibody [EPR10734(B)]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-PFKM antibody [EPR10734(B)] (AB154804)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The CYB5B protein also known as Cytochrome b5 type B is a microsomal enzyme with an approximate mass of 13.4 kDa. It resides mainly in the endoplasmic reticulum membrane playing a role in electron transfer activities. This protein is expressed in various tissues with notable presence in the liver and adrenal glands. Unlike its mitochondrial counterparts CYB5B is involved in several mixed-function oxidase systems contributing to the catalysis of reactions through electron transfer.
Biological function summary

Cytochrome b5 type B interacts with a wide range of oxidoreductase enzymes which assists in lipid biosynthesis. It acts as a component of the electron transport chain within the endoplasmic reticulum supporting the desaturation and elongation of fatty acids. Though not part of a larger complex its role in electron donation is critical for maintaining cellular lipid homeostasis and synthesizing essential fatty acids.

Pathways

CYB5B plays a role in both the fatty acid metabolic process and the sterol biosynthetic pathway. It provides electrons to desaturase enzymes like stearoyl-CoA desaturase facilitating the transformation of saturated fatty acids into unsaturated fatty acids. This electron relay is also integral to the modulation of cholesterol levels within cells and relates to proteins such as NADH-cytochrome b5 reductase that help transfer electrons from NADH to cytochrome b5.

CYB5B alterations can impact conditions such as fatty liver disease and adrenal hyperplasia. Its functional collaboration with enzymes such as cytochrome P450 isoforms can influence steroid hormone biosynthesis especially in adrenal tissues. The dysregulation of CYB5B activity might affect lipid metabolic stability making it a point of interest in understanding lipid-associated metabolic and endocrine disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.
See full target information CYB5B
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

BMC cancer 24:534 PubMed38671413

2024

Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China.

Applications

Unspecified application

Species

Unspecified reactive species

Chenxi Li,Muqiu Li,Wei Wei,Zhengye Wang,Jingwen Yu,Zhongcheng Gong
제품이 사용된 논문 모두 보기
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Product promise

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