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AB237813

Anti-CYB5R2 antibody

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(1 출판물)

Rabbit Polyclonal CYB5R2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CYB5R2.

대체 명칭 보기

NADH-cytochrome b5 reductase 2, b5R.2, CYB5R2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYB5R2 antibody (AB237813)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYB5R2 antibody (AB237813)

Paraffin-embedded human testis tissue stained for CYB5R2 using ab237813 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CYB5R2.

Q6BCY4

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보완 제품

Primary Antibodies

AB37910

Anti-TIGAR antibody

Immunocytochemistry/ Immunofluorescence - Anti-TIGAR antibody (AB37910)

  • 4
  • 3
Primary Antibodies

AB236612

Anti-CYB5B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYB5B antibody (AB236612)

  • 0
  • 0
Proteins & Peptides

AB180333

Recombinant Human CYB5R2 protein - BSA and Azide free (His tag N-Terminus)

SDS-PAGE - Recombinant Human CYB5R2 protein - BSA and Azide free (His tag N-Terminus) (AB180333)

  • 0
  • 0
Primary Antibodies

AB209847

Anti-Hexokinase II antibody [EPR20839]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-Hexokinase II antibody [EPR20839] (AB209847)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The CYB5R2 target also known as cytochrome b5 reductase 2 functions as an enzyme involved in electron transfer processes. It catalyzes the reduction of cytochrome b5 using NADH as an electron donor playing a critical role in the redox reactions. The molecular mass of CYB5R2 is approximately 34 kDa. This protein shows expression in multiple tissues including the liver and testis which suggests its widespread importance in cellular processes.
Biological function summary

Cytochrome b5 reductase 2 facilitates fatty acid desaturation and elongation. This protein does not function alone but often participates as part of larger enzyme complexes. In particular CYB5R2 operates in electron transport processes that are essential for maintaining cellular oxidation-reduction balance. Its activity in these processes highlights its role in maintaining metabolic homeostasis.

Pathways

CYB5R2 engages in fatty acid metabolism and lipid biosynthesis pathways. The protein collaborates with cytochrome P450 enzymes to contribute to lipid modification. These pathways play fundamental roles in energy storage and membrane structure which are necessary for cell function and survival. CYB5R2 shows interactivity with proteins such as CYB5A highlighting the intricate network of cellular electron transport.

Mutations or dysregulation in cytochrome b5 reductase 2 have associations with methemoglobinemia and certain cancers. Methemoglobinemia emerges due to the inability to effectively reduce methemoglobin to hemoglobin causing inefficient oxygen delivery to tissues. The connection with CYB5R2 in this disease involves its critical function in electron transfer. Additionally research indicates links between variations in CYB5R2 and prostate cancer emphasizing its role in cellular growth and proliferation alongside interactions with other proteins such as CYB5A.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).
See full target information CYB5R2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

iScience 25:105503 PubMed36404924

2022

Biofabrication of synthetic human liver tissue with advanced programmable functions.

Applications

Unspecified application

Species

Unspecified reactive species

Rodrigo M Florentino,Kazutoyo Morita,Nils Haep,Takashi Motomura,Ricardo Diaz-Aragon,Lanuza A P Faccioli,Alexandra Collin de l'Hortet,Zeliha Cetin,Carla Frau,Lawrence Vernetti,Anna-Klara Amler,Alexander Thomas,Tobias Lam,Lutz Kloke,Kazuki Takeishi,D Lansing Taylor,Ira J Fox,Alejandro Soto-Gutierrez
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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