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AB110012

Anti-CYP4B1 antibody

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Rabbit Polyclonal CYP4B1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Cytochrome P450 4B1.

대체 명칭 보기

Cytochrome P450 4B1, CYPIVB1, Cytochrome P450-HP, CYP4B1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP4B1 antibody (AB110012)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CYP4B1 antibody (AB110012)

Immunohistochemistry analysis of paraffin embedded human lung carcinoma tissue, using ab110012 at 1/50. The picture on the right is treated with the synthesized peptide.

Western blot - Anti-CYP4B1 antibody (AB110012)
  • WB

Unknown

Western blot - Anti-CYP4B1 antibody (AB110012)

All lanes:

Western blot - Anti-CYP4B1 antibody (ab110012) at 1/500 dilution

All lanes:

extracts from COLO cells (5-30 ug total protein) with no immunizing peptide

Predicted band size: 59 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human Cytochrome P450 4B1. The exact immunogen used to generate this antibody is proprietary information.

P13584

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보완 제품

Primary Antibodies

AB254616

Anti-SULT2B1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SULT2B1 antibody (AB254616)

  • 0
  • 0
Primary Antibodies

AB223842

Anti-CD39 antibody [EPR20627]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD39 antibody [EPR20627] (AB223842)

  • 5
  • 6
Primary Antibodies

AB233558

Anti-NCR1/NKp46 antibody [EPR23097-35]

BOND RX™ Validated|RabMAb|Recombinant|Advanced Validation|20ul selling size

Multiplex immunohistochemistry - Anti-NCR1/NKp46 antibody [EPR23097-35] (AB233558)

  • 5
  • 2
Primary Antibodies

AB212405

Anti-CD57 antibody [NK-1] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD57 antibody [NK-1] - BSA and Azide free (AB212405)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The CYP4B1 also known as Cytochrome P450 4B1 is an enzyme part of the Cytochrome P450 family which plays a significant role in metabolizing xenobiotics and endogenous compounds. It has a molecular mass of approximately 58 kDa. This enzyme is found in various tissues with high expression levels in the lung and liver tissues. The CYP4B1 catalyzes reactions involved in the oxidation of several substrates making it important for metabolic processes.
Biological function summary

The enzyme acts mainly in the oxidation of fatty acids and other lipophilic compounds. It contributes to the activation and detoxification of xenobiotic substances. Although not a part of any large protein complex CYP4B1 works closely with its cofactors like NADPH-cytochrome P450 reductase to achieve its function. This interaction is essential for its role in the metabolic processes that maintain cellular homeostasis.

Pathways

CYP4B1 is involved in both the arachidonic acid metabolism and the eicosanoid synthesis pathways. These pathways are significant for producing signaling molecules that regulate inflammation and other physiological functions. CYP4B1 interacts with proteins such as ALOX5 (arachidonate 5-lipoxygenase) within these pathways contributing to the complex network that controls inflammatory responses and other related bioactivities.

Investigations have connected CYP4B1 to carcinogenesis and inflammatory lung diseases. Abnormal CYP4B1 function is often associated with cancer due to its role in metabolic activation of certain procarcinogens. It also shows a relationship with lung inflammation where its activity may influence disease progression. During these conditions alterations in CYP4B1 activity can modify the bioavailability of signaling molecules linking it to other proteins like COX-2 (Cyclooxygenase-2) that are central in inflammation-related pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
See full target information Cytochrome P450 4B1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Genes 11: PubMed33207796

2020

Identification of Milk Fat Metabolism-Related Pathways of the Bovine Mammary Gland during Mid and Late Lactation and Functional Verification of the Gene.

Applications

Unspecified application

Species

Unspecified reactive species

Yongliang Fan,Ziyin Han,Xubin Lu,Huimin Zhang,Abdelaziz Adam Idriss Arbab,Juan J Loor,Yi Yang,Zhangping Yang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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