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AB9383

Anti-Cytokeratin 10 + 13 antibody [DE-K13]

4

(2 리뷰들)

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(1 출판물)

Mouse Monoclonal Cytokeratin 10 antibody. Suitable for IHC-Fr and reacts with Zebrafish samples. Cited in 1 publication. Immunogen corresponding to Full Length Protein corresponding to Human KRT10.
1 이미지
Immunohistochemistry (Frozen sections) - Anti-Cytokeratin 10 + 13 antibody [DE-K13] (AB9383)
  • IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-Cytokeratin 10 + 13 antibody [DE-K13] (AB9383)

Immunofluorescence staining of a 7 days old zebrafish embryo

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

DE-K13

Isotype

IgG2a

Light chain 타입

kappa

Carrier free

No

Reacts with

Zebrafish

Applications

IHC-Fr

applications

Immunogen

Full Length Protein corresponding to Human KRT10. The exact immunogen used to generate this antibody is proprietary information.

P13645

Specificity

This antibody reacts with cytokeratin 10 and 13 in fixed cells and frozen tissue, but exclusively with cytokeratin 13 in formalin fixed paraffin embedded tissue.

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보완 제품

Primary Antibodies

AB119695

Anti-Cytokeratin 14 antibody [SP53]

BOND RX™ Validated|20ul selling size|RabMAb|Advanced Validation|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Cytokeratin 14 antibody [SP53] (AB119695)

  • 5
  • 6
Primary Antibodies

AB52635

Anti-Cytokeratin 5 antibody [EP1601Y] - Cytoskeleton Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cytokeratin 5 antibody [EP1601Y] - Cytoskeleton Marker (AB52635)

  • 5
  • 11
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB85679

Anti-Loricrin antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Loricrin antibody (AB85679)

  • 5
  • 11
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Zebrafish": { "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "<p>Reacts with cytokeratin 10 and 13 in frozen tissues.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Preservative: 0.09% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Cytokeratin 10 and 13 also known as CK10 and CK13 are intermediate filament proteins part of the keratin family. Cytokeratin 10 has a molecular mass of approximately 59 kDa while cytokeratin 13 weighs about 53 kDa. Expression of these proteins occurs mainly in the stratified epithelium like that found in the epidermis and certain mucosal tissues. Their mechanical role includes maintaining structural integrity and providing resilience to epithelial cells against mechanical stress.
Biological function summary

Cytokeratin 10 and 13 play important roles in the differentiation and development of epithelial tissues. As components of the cytoskeletal network they aid in cell adhesion migration and intracellular signaling. These proteins integrate into a complex of intermediate filaments that support cellular architecture collaborating with other cytokeratins to sustain cellular framework.

Pathways

Cytokeratin 10 and 13 participate in the keratinization process essential for skin homeostasis. They are integral to the epidermal differentiation complex which includes interactions with proteins like loricrin and filaggrin. These pathways ensure proper formation of the skin barrier and prevent water loss maintaining skin's protective function.

Cytokeratin 10 and 13 are associated with conditions such as Ichthyosis with confetti and oral cancer. Altered expression or mutations can lead to disruptions in epithelial differentiation contributing to disease pathogenesis. Their involvement with proteins like p63 and other keratins links them to hereditary skin disorders where impaired regulation of the keratinocyte life cycle manifests as clinical symptoms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role in the establishment of the epidermal barrier on plantar skin (By similarity). Involved in the maintenance of cell layer development and keratin filament bundles in suprabasal cells of the epithelium (By similarity).. (Microbial infection) Acts as a mediator of S.aureus adherence to desquamated nasal epithelial cells via clfB, and hence may play a role in nasal colonization.. (Microbial infection) Binds S.pneumoniae PsrP, mediating adherence of the bacteria to lung cell lines. Reduction of levels of KRT10 keratin decrease adherence, overexpression increases adherence. Neither protein has to be glycosylated for the interaction to occur.
See full target information KRT10

Additional targets

Keratin, type I cytoskeletal 13

대체 명칭 보기

KPP, KRT10, Cytokeratin-10, Keratin-10, CK-10, K10, Cytokeratin-13, Keratin-13, CK-13, K13, KRT13
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Mucosal immunology 6:776-86 PubMed23187317

2012

The adult penile urethra is a novel entry site for HIV-1 that preferentially targets resident urethral macrophages.

Applications

Unspecified application

Species

Human

Y Ganor,Z Zhou,J Bodo,D Tudor,J Leibowitch,D Mathez,A Schmitt,M-C Vacher-Lavenu,M Revol,M Bomsel
제품이 사용된 논문 모두 보기
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Product promise

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