AB235531

Anti-DDX19A antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal DDX19A antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DDX19A.

대체 명칭 보기

DDX19L, DDX19A, ATP-dependent RNA helicase DDX19A, DDX19-like protein, DEAD box protein 19A

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX19A antibody (AB235531)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX19A antibody (AB235531)

Paraffin-embedded human prostate cancer tissue stained for DDX19A using ab235531 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX19A antibody (AB235531)

Paraffin-embedded human ovarian cancer tissue stained for DDX19A using ab235531 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human DDX19A.

Q9NUU7

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DDX19A also known as ATP-dependent RNA helicase DDX19A is a protein that functions mechanically as an RNA helicase. It unwinds RNA structures using energy derived from ATP hydrolysis. This protein has a mass of approximately 48 kDa. DDX19A predominantly expresses in the cytoplasm and nucleus of cells. Its function as an RNA helicase is integral to processes like RNA export where it facilitates the remodeling of RNA-protein complexes contributing to the dynamic RNA lifecycle in eukaryotic cells.

Biological function summary

DDX19A plays roles in mRNA export and ribosome biogenesis. It interacts with components of the nuclear pore complex assisting in the transport of mRNA from the nucleus to the cytoplasm. DDX19A's activity is critical for maintaining the proper flow and translation of genetic information. Through its involvement in ribosome biogenesis it aids the assembly of the ribosomal subunits which are essential for protein synthesis. The interaction of DDX19A with proteins such as NUP214 illustrates its participation in larger complexes fundamental to nuclear-cytoplasmic transport.

Pathways

DDX19A is involved in the mRNA export pathway and ribosome biogenesis pathway. These pathways ensure efficiency in gene expression and protein production. DDX19A mechanistically collaborates with proteins like Gle1 and DDX helicase family members which play supportive roles in these pathways. Its role in these interconnected processes highlights the importance of DDX19A in cellular homeostasis and response to cellular stress.

Disruptions in DDX19A function have links to acute myeloid leukemia (AML) and intellectual disabilities. AML involves abnormal functioning of DDX19A leading to disrupted mRNA export impacting gene expression profiles in leukemic cells. Interactions with proteins like NUP214 in this context underline its involvement in leukemogenesis. Additionally mutations or aberrant expression of DDX19A associate with intellectual disabilities likely due to impaired mRNA processing or ribosome production affecting brain development and function.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

ATP-dependent RNA helicase involved in mRNA export from the nucleus. Rather than unwinding RNA duplexes, DDX19 functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins.

See full target information DDX19A

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cellular oncology (Dordrecht) 46:1493-1507 PubMed37219768

2023

TRIM17-mediated ubiquitination and degradation of RBM38 promotes cisplatin resistance in non-small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Tian Zhong,Jing Zhang,Xingren Liu,Hongmin Li

Frontiers in oncology 11:629974 PubMed33968728

2021

DDX19A Promotes Metastasis of Cervical Squamous Cell Carcinoma by Inducing NOX1-Mediated ROS Production.

Applications

Unspecified application

Species

Unspecified reactive species

Yanhui Jiang,Baibin Wang,Yongliang Li,Jiahui Shen,Yutao Wei,Hanjie Li,Shangqiu Chen,Hua Yang,Famin Zeng,Changqing Liu,Feng Wang,Huanhuan He,Yong Chen,Jihong Liu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DDX19A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX19A antibody (AB235531)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DDX19A antibody (AB235531)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise