AB230787

Anti-Desmoglein 4 antibody

Be the first to review this product! 리뷰 제출

(1 출판물)

Rabbit Polyclonal Desmoglein 4 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DSG4 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

CDHF13, DSG4, Desmoglein-4, Cadherin family member 13

3 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 4 antibody (AB230787)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 4 antibody (AB230787)

Formalin-fixed, paraffin-embedded human prostate tissue stained for Desmoglein 4 with ab230787 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 4 antibody (AB230787)

Formalin-fixed, paraffin-embedded human lung respiratory epithelium tissue stained for Desmoglein 4 with ab230787 at 1/100 dilution in immunohistochemical analysis.

Supplier Data

Western blot - Anti-Desmoglein 4 antibody (AB230787)

All lanes:

Western blot - Anti-Desmoglein 4 antibody (ab230787) at 1/500 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate

Lane 2:

SP2/0 whole cell lysate

Lane 3:

H9c2 (rat heart myoblast cell line) whole cell lysate

Predicted band size: 114 kDa

true

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human DSG4 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q86SJ6

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": " Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "" } } }

style

left-column

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.3 Preservative: 0.01% Sodium azide Constituents: PBS, 30% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Desmoglein 4 (DSG4) is a cadherin protein that contributes to cell adhesion in epithelial tissue. Measuring approximately 120 kDa in mass it is an important component of desmosomes which are specialized structures facilitating cell-cell adhesion. DSG4 expression occurs in tissues such as hair follicles and skin where it supports the structural integrity of the cells. It is sometimes referred to in the context of structural proteins involved in maintaining epithelial tissue cohesion and function.

Biological function summary

Desmosomal cadherin proteins like DSG4 play significant roles in maintaining tissue architecture and enabling mechanical strength. DSG4 is a part of the desmosome adhesion complex working in concert with other desmogleins and desmocollins to anchor intermediate filaments. This network allows cells to withstand mechanical stress particularly in tissues subjected to friction or shearing forces. DSG4’s function supports stability and resilience ensuring proper tissue morphology.

Pathways

DSG4 is central to the desmosome biological pathway which also involves prominent interactions with plakoglobin and desmoplakin. These proteins together form a robust framework that stabilizes cell junctions in epithelial layers. DSG4’s interplay with keratin intermediate filaments is important for maintaining cellular integrity within the keratinization and epidermal development pathways. The protein interactions within these pathways highlight the vital structural role DSG4 contributes to epithelial cellular systems.

Mutations or disruptions in DSG4 are linked to diseases such as localized autosomal recessive hypotrichosis and monilethrix. These hair shaft disorders reflect DSG4's critical role in hair follicle development and maintenance. In these conditions abnormalities in desmoglein proteins can compromise tissue architecture leading to phenotypic manifestations like sparse hair or defective hair structure. DSG4 alongside other desmosome components like plakophilin highlights the intertwined nature of cellular adhesion and specific clinical pathologies.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (By similarity).

See full target information DSG4

style

left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Clinical cancer research : an official journal of the American Association for Cancer Research 25:1838-1850 PubMed30504427

2018

Expression of MT4-MMP, EGFR, and RB in Triple-Negative Breast Cancer Strongly Sensitizes Tumors to Erlotinib and Palbociclib Combination Therapy.

Applications

Unspecified application

Species

Unspecified reactive species

Pierre Foidart,Cassandre Yip,Jean Radermacher,Silvia Blacher,Mehdi Lienard,Laetitia Montero-Ruiz,Erik Maquoi,Elodie Montaudon,Sophie Château-Joubert,Joëlle Collignon,Michel Coibion,Véronique Jossa,Elisabetta Marangoni,Agnès Noël,Nor Eddine Sounni,Guy Jerusalem

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Desmoglein 4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 4 antibody (AB230787)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Desmoglein 4 antibody (AB230787)

Western blot - Anti-Desmoglein 4 antibody (AB230787)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise