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AB235100

Anti-DHX32 antibody

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Rabbit Polyclonal DHX32 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DHX32 aa 300-500.

대체 명칭 보기

DDX32, DHX32, Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32, DEAD/H box 32, DEAD/H helicase-like protein 1, DEAH box protein 32, HuDDX32, DHLP1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHX32 antibody (AB235100)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHX32 antibody (AB235100)

Paraffin-embedded human testis tissue stained for DHX32 using ab235100 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHX32 antibody (AB235100)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DHX32 antibody (AB235100)

Paraffin-embedded human kidney tissue stained for DHX32 using ab235100 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DHX32 aa 300-500. The exact immunogen used to generate this antibody is proprietary information.

Q7L7V1

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보완 제품

Primary Antibodies

AB154961

Anti-MRPL12 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL12 antibody (AB154961)

  • 0
  • 0
Primary Antibodies

AB209483

Anti-UCP1 antibody [EPR20381]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UCP1 antibody [EPR20381] (AB209483)

  • 5
  • 4
Reagents, Controls & Accessories

AB110412

Total OXPHOS Blue Native WB Antibody Cocktail

Western blot - Total OXPHOS Blue Native WB Antibody Cocktail (AB110412)

  • 5
  • 1
Primary Antibodies

AB189945

Anti-SDHD antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SDHD antibody (AB189945)

  • 5
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DHX32 also known as DExH-box helicase 32 is a member of the DEAH-box family of RNA helicases. With a mass of approximately 84 kDa DHX32 plays important roles in unwinding RNA secondary structures facilitating processes like RNA splicing and ribosome biogenesis. This protein is highly expressed in various tissues with notable abundance in lymphoid tissues suggesting its involvement in immune function. Its ATP-dependent RNA helicase activity makes it central to post-transcriptional regulation and RNA metabolism.
Biological function summary

DHX32 contributes to the regulation of RNA-related processes. By being part of larger ribonucleoprotein complexes it influences the maturation and processing of ribosomal RNA pre-mRNA splicing and other RNA metabolic pathways. Its function in these complexes ensures the proper assembly and function of the ribosomes which is essential for protein synthesis. The helicase activity provides the energy necessary for these molecular events directly impacting the efficiency and fidelity of RNA processing.

Pathways

Research has indicated that DHX32 is involved in both the spliceosome assembly pathway and the ribosome biogenesis pathway. Within these pathways DHX32 interacts with proteins such as SF3A1 and U2AF2 in the splicing machinery and nucleophosmin (NPM1) in ribosome assembly. These interactions connect DHX32 to a broader network of proteins and ensure the pathways proceed correctly affecting cellular growth and maintenance processes.

DHX32 has shown associations with lymphomas and leukemias reflecting its expression in lymphoid tissues. Its interaction with proteins like c-Myc a well-known oncogene links DHX32 to the regulation of cellular proliferation and survival. These interactions suggest that dysregulation of DHX32 can contribute to the development of malignancies by altering RNA processing and protein synthesis highlighting its potential as a target for therapeutic approaches.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information DHX32
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 16: PubMed38611046

2024

FXR Agonism with Bile Acid Mimetic Reduces Pre-Clinical Triple-Negative Breast Cancer Burden.

Applications

Unspecified application

Species

Unspecified reactive species

Sydney C Joseph,Samson Eugin Simon,Margaret S Bohm,Minjeong Kim,Madeline E Pye,Boston W Simmons,Dillon G Graves,Stacey M Thomas-Gooch,Ubaid A Tanveer,Jeremiah R Holt,Suriyan Ponnusamy,Laura M Sipe,D Neil Hayes,Katherine L Cook,Ramesh Narayanan,Joseph F Pierre,Liza Makowski
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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