AB222895

Anti-DMRT1 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal DMRT1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DMRT1 aa 150 to C-terminus.

대체 명칭 보기

DMT1, DMRT1, Doublesex- and mab-3-related transcription factor 1, DM domain expressed in testis protein 1

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRT1 antibody (AB222895)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRT1 antibody (AB222895)

Paraffin-embedded human breast cancer tissue stained for DMRT1 using ab222895 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRT1 antibody (AB222895)

Paraffin-embedded human testis tissue stained for DMRT1 using ab222895 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DMRT1 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y5R6

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The DMRT1 protein also known as Doublesex and Mab-3 related transcription factor 1 plays a mechanical role in sex determination and differentiation. This protein with an approximate mass of 40 kDa functions primarily as a transcription factor. DMRT1 is expressed in the gonads particularly in testicular tissues where it contributes to the development and maintenance of male-specific traits. The DMRT1 gene located on chromosome 9 in humans encodes this zinc finger-like DNA binding protein.

Biological function summary

The DMRT1 protein regulates the expression of other genes that are essential for male sexual development and spermatogenesis. As part of its biological role DMRT1 is an important factor in the formation of testicular structures and ensures the survival of male germ cells. The protein functions as part of complexes that interact with other transcriptional regulators to modulate gene activity. By exerting control over male-biased gene expression DMRT1 helps maintain the balance of sex-specific pathways while suppressing genes linked to female differentiation.

Pathways

The DMRT1 protein acts as a central player in the sex determination and development pathways. It is involved in the testis differentiation pathway which includes interactions with SOX9 and other transcription factors like SF1. DMRT1 also associates with pathways influencing Sertoli cell proliferation and function which are key in sustaining spermatogenesis. The engagement of DMRT1 in these pathways highlights its interconnected role with proteins that oversee reproductive development and function.

The DMRT1 protein shows connections to sex development disorders and testicular cancers. Abnormalities in DMRT1 expression or function can result in conditions like gonadal dysgenesis due to disrupted testicular differentiation. Testicular cancer also associates with altered DMRT1 activity. In these contexts mutations in DMRT1 or interacting partners like AMH have been linked with deviations from normal testicular development or tumorigenesis illustrating important clinical relevance and potential therapeutic interest.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator : prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization : represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).

See full target information DMRT1

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Discover. Oncology 14:25 PubMed36820928

2023

High dose isoleucine stabilizes nuclear PTEN to suppress the proliferation of lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Haiqing Wang,Sen Chen,Wenhui Kang,Bojiao Ding,Shulan Cui,Li Zhou,Na Zhang,Huiying Luo,Mingjuan Wang,Fan Zhang,Zezhou Zhao,Zihu Guo,Chao Wang,Liang Li,Zhengzhong Wang,Xuetong Chen,Yonghua Wang

Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 17:32-42 PubMed36746123

2023

Testicular Architecture of Men with 46,XX Testicular Disorders of Sex Development.

Applications

Unspecified application

Species

Unspecified reactive species

Mirkka Hiort,Julia Rohayem,Regine Knaf,Sandra Laurentino,Agnethe Berglund,Claus H Gravholt,Jörg Gromoll,Joachim Wistuba

Oxidative medicine and cellular longevity 2022:9657933 PubMed35154576

2022

Ferrostatin-1 and 3-Methyladenine Ameliorate Ferroptosis in OVA-Induced Asthma Model and in IL-13-Challenged BEAS-2B Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Yang,Yunxiao Shang

Cell metabolism 28:268-281.e4 PubMed29937374

2018

Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1.

Applications

Unspecified application

Species

Unspecified reactive species

Miriam Toledo,Ana Batista-Gonzalez,Emilio Merheb,Marie Louise Aoun,Elena Tarabra,Daorong Feng,Jaakko Sarparanta,Paola Merlo,Francesco Botrè,Gary J Schwartz,Jeffrey E Pessin,Rajat Singh

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-DMRT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRT1 antibody (AB222895)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRT1 antibody (AB222895)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise