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AB238679

Anti-DMRTA1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal DMRTA1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human DMRTA1 aa 200 to C-terminus.

대체 명칭 보기

DMO, DMRTA1, Doublesex- and mab-3-related transcription factor A1

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRTA1 antibody (AB238679)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DMRTA1 antibody (AB238679)

Paraffin-embedded human colon cancer tissue stained for DMRTA1 using ab238679 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human DMRTA1 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q5VZB9

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보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB154193

Anti-Von Willebrand Factor antibody [EPSISR15]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Von Willebrand Factor antibody [EPSISR15] (AB154193)

  • 0
  • 0
Primary Antibodies

AB234832

Anti-ZMPSTE24 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMPSTE24 antibody (AB234832)

  • 0
  • 0
Primary Antibodies

AB267377

Anti-Wilms Tumor Protein antibody [EPR23963-116]

BOND RX™ Validated|20ul selling size|Recombinant|KO Validated|Advanced Validation|RabMAb

Multiplex immunohistochemistry - Anti-Wilms Tumor Protein antibody [EPR23963-116] (AB267377)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DMRTA1 also known as Doublesex and Mab-3 related transcription factor A1 is a protein with a mass of approximately 54 kDa. This protein acts as a transcription factor and is involved in regulating gene expression. DMRTA1 is primarily expressed in the brain with high levels found in the cerebellum and frontal cortex. Researchers have also observed expression in testis and ovary tissues suggesting a role in reproductive system development.
Biological function summary

DMRTA1 influences sex determination and differentiation. It functions as part of the larger DMRT family of proteins which share a common DM domain. This domain allows DMRTA1 to bind to DNA and regulate gene transcription essential for sexual development. In mammals DMRTA1 is not typically known to form complex structures with other proteins but its role as a transcription factor indicates interaction with various cofactors during gene regulation.

Pathways

The role of DMRTA1 lies within the sexual development pathway and the broader context of embryonic development. It interacts with critical signaling proteins like SOX9 an important player in testis development and function. DMRTA1 complements the activity of WT1 another important transcription factor involved in gonadal development and differentiation further emphasizing its involvement in these pathways.

Altered DMRTA1 expression associates with disorders of sex development (DSDs) potentially leading to ambiguous genitalia or gonadal dysgenesis. Research suggests that DMRTA1 might also have connections with cancer particularly germ cell tumors due to its expression in reproductive tissues. In these contexts DMRTA1 may interact with other proteins such as GATA4 Well-characterized for its role in sex differentiation and tumorigenesis in reproductive organs.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information DMRTA1
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 16:6347 PubMed40634286

2025

Early developmental origins of cortical disorders modeled in human neural stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xoel Mato-Blanco,Suel-Kee Kim,Alexandre Jourdon,Shaojie Ma,Sang-Hun Choi,Alice M Giani,Miguel I Paredes,Andrew T N Tebbenkamp,Fuchen Liu,Alvaro Duque,Flora M Vaccarino,Nenad Sestan,Carlo Colantuoni,Pasko Rakic,Gabriel Santpere,Nicola Micali

Toxins 14: PubMed35050979

2021

Molecular Characterization and Functional Analysis of the Nattectin-like Toxin from the Venomous Fish .

Applications

Unspecified application

Species

Unspecified reactive species

Monica Lopes-Ferreira,Ines Sosa-Rosales,Pedro Ismael Silva Junior,Katia Conceicao,Adolfo Luis Almeida Maleski,Leticia Balan-Lima,Geonildo Rodrigo Disner,Carla Lima
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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