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AB240690

Anti-DMXL2 antibody

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Rabbit Polyclonal DMXL2 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human DMXL2 aa 1450 to C-terminus.

대체 명칭 보기

KIAA0856, DMXL2, DmX-like protein 2, Rabconnectin-3

2 이미지
Immunoprecipitation - Anti-DMXL2 antibody (AB240690)
  • IP

Supplier Data

Immunoprecipitation - Anti-DMXL2 antibody (AB240690)

DMXL2 immunoprecipitated from Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN lysis buffer. Western blot was performed from the immunoprecipitate using ab240690 at 1/100 dilution.

Lane 1 : ab240690 used for IP at 20 μl per reaction in Jurkat whole cell lysate.
Lane 2 : Control IgG iP in Jurkat whole cell lysate.

Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-DMXL2 antibody (ab240690)

Predicted band size: 340 kDa

false

Western blot - Anti-DMXL2 antibody (AB240690)
  • WB

Supplier Data

Western blot - Anti-DMXL2 antibody (AB240690)

Lysates prepared using NETN lysis buffer.

All lanes:

Western blot - Anti-DMXL2 antibody (ab240690) at 1/1000 dilution

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate at 50 µg

Lane 2:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 50 µg

Lane 3:

Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate at 50 µg

Predicted band size: 340 kDa

true

Exposure time: 3min

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP, WB

applications

Immunogen

Synthetic Peptide within Human DMXL2 aa 1450 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TDJ6

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대체품

Primary Antibodies

AB234771

Anti-DMXL2 antibody

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  • 0
  • 0

보완 제품

Primary Antibodies

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Primary Antibodies

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Primary Antibodies

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Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y]

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Western blot - Anti-Alpha-synuclein (phospho S129) antibody [EP1536Y] (AB51253)

  • 5
  • 9
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p>Use 20 μl/mg lysate.</p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab240690 was affinity purified using an epitope specific to DMXL2 immobilized on solid support.
보관 버퍼
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DMXL2 also known as rabconnectin-3α is a large protein with a mass of approximately 350 kDa. It contains multiple WD40 repeats which suggests a role in protein-protein interactions. DMXL2 is expressed in various tissues with higher concentrations in the brain pituitary gland and reproductive organs. It functions mechanically in intracellular transport and signal transduction influencing neurotransmitter release and hormone secretion.
Biological function summary

DMXL2 plays a role in cellular homeostasis and communication. It is part of a protein complex associating with rab3 GTPase-activating proteins to regulate synaptic vesicle exocytosis. This protein contributes to the balance of Ca2+ dynamics in neuronal cells therefore influencing neurotransmitter release processes. Because it interacts directly with components involved in signaling DMXL2 impacts cellular responses to external stimuli.

Pathways

DMXL2 participates in the Notch signaling pathway and mTOR pathway. This protein interacts with key molecules such as rab3 a small GTPase essential for vesicle trafficking. The contribution of DMXL2 to these pathways enables it to orchestrate critical steps in cell growth proliferation and survival. By engaging in these pathways DMXL2 influences cellular metabolism and synaptic plasticity.

DMXL2 shows a connection to polycystic ovary syndrome (PCOS) and neurodegenerative disorders like Alzheimer's disease. Altered DMXL2 expression or function impacts reproductive endocrinology pathways related to PCOS where it can interact with proteins like FSH receptor. In Alzheimer's disease DMXL2's role in synaptic function ties it to amyloid-beta peptide processes an important aspect of the disease's progression. These connections highlight DMXL2 as a potential target for therapeutic intervention in these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles (PubMed : 11809763). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (By similarity).
See full target information DMXL2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Stem cell research & therapy 16:324 PubMed40597299

2025

Mesenchymal stromal cell secretome reduces lung injury and thrombo-inflammation induced by SARS-CoV-2 spike protein.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Pezzotta,Alessandra Bovio,Barbara Imberti,Monica Locatelli,Daniela Corna,Domenico Cerullo,Sara Gastoldi,Ariela Benigni,Giuseppe Remuzzi,Marina Morigi,Luca Perico
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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