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AB188558

Anti-DOCK6 antibody

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Rabbit Polyclonal DOCK6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DOCK6 aa 1150-1300.

대체 명칭 보기

KIAA1395, DOCK6, Dedicator of cytokinesis protein 6

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DOCK6 antibody (AB188558)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DOCK6 antibody (AB188558)

Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling DOCK6 with ab188558 at 1/1000 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-DOCK6 antibody (AB188558)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DOCK6 antibody (AB188558)

U-2 OS cells stained for DOCK6 (green) using ab188558 at 2 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DOCK6 aa 1150-1300. The exact immunogen used to generate this antibody is proprietary information.

Q96HP0

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보완 제품

Primary Antibodies

AB84094

Anti-PELP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PELP1 antibody (AB84094)

  • 0
  • 0
Assay Kits

AB204537

Creatinine Assay Kit (Colorimetric)

Functional Studies - Creatinine Assay Kit (Colorimetric) (AB204537)

  • 0
  • 0
Primary Antibodies

AB253201

Anti-Acetylcholinesterase antibody [EPR23268-202]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-Acetylcholinesterase antibody [EPR23268-202] (AB253201)

  • 0
  • 0
Primary Antibodies

AB217731

Alexa Fluor® 555 Anti-Cyclin A2 antibody [EPR17351]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 555 Anti-Cyclin A2 antibody [EPR17351] (AB217731)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DOCK6 or Dedicator of Cytokinesis 6 functions as a guanine nucleotide exchange factor (GEF) involved in cytoskeleton organization. This protein weighs approximately 226 kDa. It facilitates the transition between inactive GDP-bound states to active GTP-bound states for small GTPases such as Rac1 and Cdc42. Expression of DOCK6 is widespread but found prominently in neural tissues indicating its relevance in neural development and function.
Biological function summary

DOCK6 acts as an activator of Rho family GTPases which play a central role in various cellular processes including cell migration adhesion and morphology. DOCK6 does not function as part of a larger multi-protein complex but interacts selectively with other proteins to exert its biological effects. The protein is important for proper neuronal network formation influencing the branching and guidance of axons and dendrites.

Pathways

DOCK6 is involved in the Rho GTPase signaling pathway and the cell polarity establishment pathway. In the Rho GTPase signaling pathway DOCK6 interacts closely with proteins such as Rac1 and Cdc42 to modulate cytoskeletal rearrangements. These signaling pathways are key for developmental processes and defects can lead to improper cellular functions impacting tissue architecture and organogenesis.

Mutations in DOCK6 are associated with Adams-Oliver syndrome and microcephaly. Adams-Oliver syndrome which involves limb abnormalities and scalp defects has connections to DOCK6's role in cytoskeleton dynamics. Similarly its link to microcephaly comes from its effects on neuronal differentiation and proliferation. Cdc42 which operates in similar pathways shows overlapping roles in neural development and diseases connected to cytoskeletal disruptions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acts as a guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Through its activation of CDC42 and RAC1, may regulate neurite outgrowth (By similarity).
See full target information DOCK6
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Aging 16:5887-5904 PubMed38517396

2024

Cordyceps sinensis extract protects against acute kidney injury by inhibiting perforin expression in NK cells via the STING/IRF3 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Shuang Li,Wei Pang,Yuzhu Wang,Yiting Zhang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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