AB72730

Anti-DOK6 antibody

Be the first to review this product! 리뷰 제출

(3 제품이 사용된 논문 )

Rabbit Polyclonal DOK6 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human DOK6.

2 이미지

Immunocytochemistry/ Immunofluorescence - Anti-DOK6 antibody (AB72730)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DOK6 antibody (AB72730)

ab72730 at 1/500 dilution staining DOK6 in A549 cells by Immunofluorescence, in the absence or presence of the immunising peptide.

Unknown

Western blot - Anti-DOK6 antibody (AB72730)

All lanes:

Western blot - Anti-DOK6 antibody (ab72730) at 1/500 dilution

Lane 1:

COLO cell extract at 30 µg

Lane 2:

COLO cell extract at 30 µg with immunising peptide

Predicted band size: 38 kDa

Observed band size: 38 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human DOK6. The exact immunogen used to generate this antibody is proprietary information.

Q6PKX4

style

left-column

style

left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

style

left-column

특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

style

left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DOK6 known also as Docking Protein 6 is a member of the DOK family of proteins which are critical in intracellular signaling pathways. It weighs approximately 36 kDa and predominantly functions as an adaptor protein. Expression of DOK6 mainly occurs in the central nervous system particularly within neuronal tissues. It plays a fundamental role in the transmission of extracellular signals into the intracellular environment influencing various downstream effects.

Biological function summary

This protein supports neuronal differentiation and development. DOK6 does not operate alone but often combines with other proteins in signaling complexes. Its interactions enable it to regulate the signaling pathways that dictate neuronal survival growth and maturation. Research indicates that DOK6 influences cytoskeletal reorganization which is important for maintaining neuronal architecture and function.

Pathways

DOK6 serves as a significant player in the RET signaling pathway and possibly the Trk neurotrophin receptor pathway. It relates to proteins like RET and Shc contributing to these cascades. Through these pathways DOK6 assists in mediating the effects of growth factors that are essential for the growth and repair of the nervous system.

Studies have linked DOK6 to neurodevelopmental disorders and certain types of cancer. Abnormal DOK6 expression or function often correlates with conditions like Hirschsprung's disease where it interacts with RET. Research into its exact roles in these diseases continues providing hope for new therapeutic strategies.

style

left-column

style

left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

타겟 정보

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.

See full target information DOK6

대체 명칭 보기

DOK5L, DOK6, Docking protein 6, Downstream of tyrosine kinase 6

style

left-column

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Signal transduction and targeted therapy 9:32 PubMed38351062

2024

Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy.

Applications

Unspecified application

Species

Unspecified reactive species

Yan Guo,Pan Xiang,Xiaojiao Sun,Wei Liu,Jiafeng Zhou,Bin Yin,Lin Hou,Boqin Qiang,Huiliang Li,Pengcheng Shu,Xiaozhong Peng

Molecular nutrition & food research 64:e2000361 PubMed32991778

2020

Methionine- and Choline-Deficient Diet Enhances Adipose Lipolysis and Leptin Release in aP2-Cre Fatp4-Knockout Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yuting Cheng,Hongying Gan-Schreier,Jessica Seeßle,Simone Staffer,Sabine Tuma-Kellner,Denis Khnykin,Wolfgang Stremmel,Uta Merle,Thomas Herrmann,Walee Chamulitrat

Haematologica 106:1968-1978 PubMed32467143

2020

Antiplatelet properties of Pim kinase inhibition are mediated through disruption of thromboxane A2 receptor signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Amanda J Unsworth,Alexander P Bye,Tanya Sage,Renato S Gaspar,Nathan Eaton,Caleb Drew,Alexander Stainer,Neline Kriek,Peter J Volberding,James L Hutchinson,Ryan Riley,Sarah Jones,Stuart J Mundell,Weiguo Cui,Hervé Falet,Jonathan M Gibbins

제품이 사용된 논문 모두 보기

style

left-column

style

left-column

style

right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-DOK6 antibody

Immunocytochemistry/ Immunofluorescence - Anti-DOK6 antibody (AB72730)

Western blot - Anti-DOK6 antibody (AB72730)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (3)

Product promise