JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB236604

Anti-DPM1 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal DPM1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DPM1.

대체 명칭 보기

Dolichol-phosphate mannosyltransferase subunit 1, Dolichol-phosphate mannose synthase subunit 1, Dolichyl-phosphate beta-D-mannosyltransferase subunit 1, Mannose-P-dolichol synthase subunit 1, DPM synthase subunit 1, MPD synthase subunit 1, DPM1

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPM1 antibody (AB236604)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPM1 antibody (AB236604)

Paraffin-embedded human pancreas tissue stained for DPM1 using ab236604 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPM1 antibody (AB236604)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPM1 antibody (AB236604)

Paraffin-embedded human kidney tissue stained for DPM1 using ab236604 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-DPM1 antibody (AB236604)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-DPM1 antibody (AB236604)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for DPM1 (green) using ab236604 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human DPM1.

O60762

style
left-column

대체품

Primary Antibodies

AB113686

Anti-DPM1 antibody [5C5A7]

Western blot - Anti-DPM1 antibody [5C5A7] (AB113686)

  • 3
  • 1

보완 제품

Primary Antibodies

AB113683

Anti-VPH1 antibody [10D7A7B2]

Western blot - Anti-VPH1 antibody [10D7A7B2] (AB113683)

  • 3
  • 1
Primary Antibodies

AB96803

Anti-ATP6V0A2 antibody

  • 0
  • 0
Primary Antibodies

AB237532

Anti-SPTLC3 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SPTLC3 antibody (AB237532)

  • 0
  • 0
Primary Antibodies

AB157458

Anti-ATP6V1D antibody [EPR11326(B)]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP6V1D antibody [EPR11326(B)] (AB157458)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DPM1 also known as dolichyl-phosphate beta-D-mannosyltransferase subunit 1 is an important component of the dolichol-phosphate mannose synthase complex. It has a molecular mass of approximately 29 kDa. DPM1 is localized in the endoplasmic reticulum membrane where it plays a significant role in the synthesis of glycosylphosphatidylinositol (GPI) anchors and protein glycosylation.
Biological function summary

This protein is essential in transferring mannose from GDP-mannose to dolichol phosphate a reaction that synthesizes dolichol-phosphate mannose (DPM). DPM is an important donor substrate in the glycan assembly pathways. DPM1 does not have a transmembrane domain unlike other components of the DPM synthase complex. Association with other complex subunits like DPM2 and DPM3 stabilize its structure and function within the cell ensuring glycosylation processes proceed correctly.

Pathways

Glycosylation is one of the fundamental pathways DPM1 participates in. Its role in glycosylation links it to the protein N-glycosylation pathway and GPI anchor biosynthesis pathway. DPM1 interacts with proteins such as DPM2 in the synthase complex to facilitate the conversion process necessary for glycosylation of proteins and lipids impacting various cellular processes like cell-cell adhesion and protein folding.

DPM1 molecule relates to congenital disorders of glycosylation (CDG) particularly CDG-Ie. Mutations in the gene encoding DPM1 can disrupt enzymatic activity leading to issues in glycosylation which manifest in multisystem disorders. The connection of DPM1 to these disorders often involves deficiencies in dolichol-phosphate mannose production. Similarly defects in associated proteins like DPM2 can compound the glycosylation defects exacerbating disease symptoms.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex.
See full target information DPM1
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 24: PubMed37373386

2023

Hif1α/Dhrs3a Pathway Participates in Lipid Droplet Accumulation via Retinol and Ppar-γ in Fish Hepatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jingjing Tian,Yihui Du,Binbin Wang,Mengmeng Ji,Hongyan Li,Yun Xia,Kai Zhang,Zhifei Li,Wenping Xie,Wangbao Gong,Ermeng Yu,Guangjun Wang,Jun Xie
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com