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AB230236

Anti-DPT/TRAMP antibody

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(1 출판물)

Rabbit Polyclonal DPT/TRAMP antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Dermatopontin aa 1 to C-terminus.

대체 명칭 보기

Dermatopontin, Tyrosine-rich acidic matrix protein, TRAMP, DPT

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPT/TRAMP antibody (AB230236)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPT/TRAMP antibody (AB230236)

Paraffin-embedded human pancreatic tissue stained for DPT/TRAMP using ab230236 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Dermatopontin aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q07507

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대체품

Primary Antibodies

AB221576

Anti-DPT/TRAMP antibody

Immunocytochemistry/ Immunofluorescence - Anti-DPT/TRAMP antibody (AB221576)

  • 3
  • 2
Primary Antibodies

AB255823

Anti-DPT/TRAMP antibody [EPR22845-83]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-DPT/TRAMP antibody [EPR22845-83] (AB255823)

  • 0
  • 0
Primary Antibodies

AB256824

Anti-DPT/TRAMP antibody [EPR22845-83] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-DPT/TRAMP antibody [EPR22845-83] - BSA and Azide free (AB256824)

  • 0
  • 0

보완 제품

Assay Kits

AB272206

Human DPT ELISA Kit (TRAMP)

Recombinant|SimpleStep

ELISA - Human DPT ELISA Kit (TRAMP) (AB272206)

  • 0
  • 0
Proteins & Peptides

AB322091

Recombinant Human DPT Protein Standard (His tag)

Sandwich ELISA - Recombinant Human DPT Protein Standard (His tag) (AB322091)

  • 0
  • 0
Primary Antibodies

AB14041

Anti-Periostin antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Periostin antibody (AB14041)

  • 5
  • 20
Assay Kits

AB253341

Human DPT Antibody Pair - BSA and Azide free (TRAMP)

RabMAb|Recombinant

Sandwich ELISA - Human DPT Antibody Pair - BSA and Azide free (TRAMP) (AB253341)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DPT also known as Dermatopontin is a protein with a molecular mass of approximately 22 kDa. It is expressed in various tissues with high expression levels in the skin heart and lungs. Dermatopontin interacts with extracellular matrix components and influences cell adhesion and matrix organization. The protein plays a role in regulating fibroblast activity and collagen binding making it important in connective tissue structure and function.
Biological function summary

Dermatopontin contributes to maintaining dermal structural integrity and facilitating wound healing. As part of a larger protein interaction network it enhances cellular communication and tissue repair processes. Dermatopontin modulates the bioavailability of TGF-beta which is essential for collagen production and tissue homeostasis. This highlights its presence in skin remodeling and repair mechanisms linking it to new tissue formation.

Pathways

Dermatopontin participates actively in the TGF-beta signaling pathway and the ECM-receptor interaction pathway. These pathways are critical for cellular communication and tissue structuring processes. The protein interacts with Integrins and Fibronectin facilitating cell-to-ECM adhesion and remodeling activities. Consequently Dermatopontin's pathway involvement supports dynamic tissue responses such as healing and functional adaptation to environmental changes.

Dermatopontin shows associations with fibrosis and keloids. These disorders feature aberrant tissue formation and scarring wherein DPT's regulation of fibroblasts and collagen dynamics plays a notable role. Additionally Dermatopontin's interactions with other proteins like Collagen VI and Decorin influence its involvement in these conditions contributing to the understanding of pathological tissue remodeling mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
See full target information Dermatopontin
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cells 12: PubMed36611882

2022

Human Placental Endothelial Cell and Trophoblast Heterogeneity and Differentiation Revealed by Single-Cell RNA Sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Han Li,Hao Peng,Wei Hong,Yingying Wei,Haojun Tian,Xiaojie Huang,Linyan Jia,Jing Zheng,Tao Duan,Qizhi He,Kai Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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