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AB121844

Anti-DPYS antibody

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Rabbit Polyclonal DPYS antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DPYS aa 400 to C-terminus.

대체 명칭 보기

Dihydropyrimidinase, DHP, DHPase, Dihydropyrimidine amidohydrolase, Hydantoinase, DPYS

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-DPYS antibody (AB121844)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-DPYS antibody (AB121844)

Immunofluorescent staining of Human cell line A-431 shows positivity in vesicles and centrosome. Recommended concentration of ab121844 1-4 µg/ml. Cells treated with PFA/Triton X-100.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPYS antibody (AB121844)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPYS antibody (AB121844)

ab121844 at 1/500 dilution staining DPYS in Paraffin-embedded Human kidney tissue by Immunohistochemistry.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DPYS aa 400 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q14117

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대체품

Primary Antibodies

AB205039

Anti-DPYS antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DPYS antibody (AB205039)

  • 0
  • 0

보완 제품

Primary Antibodies

AB11878

Anti-C5a / C5a des Arg antibody [2952]

  • 4
  • 1
Primary Antibodies

AB133543

Anti-Liver Arginase antibody [EPR6672(B)]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Arginase antibody [EPR6672(B)] (AB133543)

  • 5
  • 3
Primary Antibodies

AB76013

Anti-TTF1/Nkx2-1 antibody [EP1584Y]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TTF1/Nkx2-1 antibody [EP1584Y] (AB76013)

  • 5
  • 18
Primary Antibodies

AB129076

Anti-CPS1 antibody [EPR7493-3]

RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPS1 antibody [EPR7493-3] (AB129076)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1-4 µg/mL", "ICCIF-species-notes": "<p>Recommend PFA Fixation and Triton X-100 treatment</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DPYS also known as dihydropyrimidinase is an enzyme involved in the breakdown of pyrimidines specifically converting dihydropyrimidines to N-carbamyl-B-alanine. The mass of DPYS is approximately 56 kDa. This enzyme is present in various tissues most notably in the liver and kidney. DPYS plays a role in the catabolic pathway of nucleic acids facilitating the reuse and recycling of building blocks required for nucleic acid synthesis.
Biological function summary

DPYS functions as part of the larger pyrimidine degradation pathway. It does not act in isolation but may associate with other enzymes responsible for subsequent steps in this pathway. Pyrimidine metabolism is essential for maintaining the nucleotide pool balance in cells aiding cellular replication and repair processes. DPYS ensures efficient conversion of potentially harmful intermediates into products that cells can either reuse or excrete safely.

Pathways

The activity of DPYS is integrated into the pyrimidine catabolic pathway which intersects with the urea cycle. This enzyme works alongside others such as dihydropyrimidine dehydrogenase (DPYD) to facilitate pyrimidine degradation. The interactions between DPYS and DPYD are critical as they control the levels of pyrimidine metabolites in the cell preventing accumulation that could cause cellular stress or damage.

Mutations in the DPYS gene correlate with the rare metabolic disorder called dihydropyrimidinuria. This condition manifests due to the inefficient breakdown of pyrimidines leading to excessive urinary excretion of dihydropyrimidines. Furthermore impaired DPYS activity may have implications in drug metabolism particularly fluoropyrimidine-based cancer therapies as reduced activity can lead to toxicity. DPYD also connects to these conditions through its role in pyrimidine degradation highlighting the interdependence of these enzymes in both regular metabolic function and disease states.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalyzes the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines. Can catalyze the ring opening of 5,6-dihydrouracil to N-carbamyl-alanine and of 5,6-dihydrothymine to N-carbamyl-amino isobutyrate.
See full target information DPYS
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 24: PubMed36834940

2023

Inhibition of Ribosomal RNA Processing 15 Homolog (RRP15) Suppressed Tumor Growth, Invasion and Epithelial to Mesenchymal Transition (EMT) of Colon Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zirong Deng,Yun Xu,Yuchen Cai,Weiling Lin,Libei Zhang,Aoqing Jiang,Yuhang Zhou,Rui Zhao,Heyan Zhao,Zhaoguo Liu,Tingdong Yan
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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