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AB8411

Anti-DR3/LARD antibody

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Rabbit Polyclonal DR3/LARD antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human TNFRSF25 aa 350 to C-terminus.
1 이미지
Western blot - Anti-DR3/LARD antibody (AB8411)
  • WB

Unknown

Western blot - Anti-DR3/LARD antibody (AB8411)

All lanes:

Western blot - Anti-DR3/LARD antibody (ab8411) at 1/500 dilution

All lanes:

Jurkat total cell lysate

Predicted band size: 45 kDa

Observed band size: 59 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Light chain 타입

unknown

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human TNFRSF25 aa 350 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q93038

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대체품

Primary Antibodies

AB234187

Anti-DR3/LARD antibody [JD3]

Flow Cytometry - Anti-DR3/LARD antibody [JD3] (AB234187)

  • 0
  • 0
Primary Antibodies

AB234231

PE Anti-DR3/LARD antibody [JD3]

Flow Cytometry - PE Anti-DR3/LARD antibody [JD3] (AB234231)

  • 0
  • 0
Primary Antibodies

AB8412

Anti-DR3/LARD antibody

Immunocytochemistry/ Immunofluorescence - Anti-DR3/LARD antibody (AB8412)

  • 4
  • 4

보완 제품

Primary Antibodies

AB234307

Anti-TL1A antibody [VEGI/2052R]

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TL1A antibody [VEGI/2052R] (AB234307)

  • 0
  • 0
Proteins & Peptides

AB157260

Recombinant Human DR3/LARD protein

  • 0
  • 0
Primary Antibodies

AB134161

Anti-CD276 antibody [EPNCIR122]

RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-CD276 antibody [EPNCIR122] (AB134161)

  • 0
  • 0
Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

  • 5
  • 19
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The DR3 receptor also known as LARD (Lymphocyte Apoptosis-Related Receptor Domain) is a member of the TNF receptor superfamily. This protein also referred to as the DR3 protein or LARD protein is involved in mediating apoptotic signals. DR3 is expressed predominantly in lymphoid tissues and plays an important role in immune system regulation. DR3 protein has an approximate mass of 65 kDa. Scientists study DR3 in various models including cyno RNA and protein monkey models to gain better understanding of its function and expression.
Biological function summary

DR3 functions significantly in the immune response by modulating apoptosis. It forms part of a complex with other proteins leading to the activation of signaling pathways that result in cell death. The binding of its ligand TL1A to DR3 initiates a series of downstream effects that influence T-cell and other immune cell activities. LARD target has a functional correlation with the regulation of immune response and the maintenance of homeostasis in immune cell populations.

Pathways

DR3 receptor mediates signals primarily in two significant pathways: the NF-kB pathway and the MAPK pathway. These pathways play a role in transducing signals that lead to inflammation and immune responses. DR3 interacts with other proteins such as TRADD and RIPK1 facilitating the propagation of signals through these pathways. The engagement of DR3 in these pathways highlights its regulatory influence over immune cell survival and function.

DR3 plays an important role in autoimmune diseases and inflammatory disorders. Dysregulation of DR3 receptor and its signaling pathways can contribute to conditions like rheumatoid arthritis and inflammatory bowel disease. There is a notable connection between dysfunction in DR3 signaling and altered interactions with pro-inflammatory proteins such as TNF-alpha which can exacerbate these conditions. Understanding DR3's role helps in developing therapeutic approaches to manage these disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis.
See full target information TNFRSF25

대체 명칭 보기

APO3, DDR3, DR3, TNFRSF12, WSL, WSL1, UNQ455/PRO779, TNFRSF25, Tumor necrosis factor receptor superfamily member 25, Apo-3, Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Death receptor 3, Lymphocyte-associated receptor of death, Protein WSL, Protein WSL-1, LARD
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Human molecular genetics 18:4801-7 PubMed19776031

2009

Adenosine deamination in human transcripts generates novel microRNA binding sites.

Applications

Unspecified application

Species

Unspecified reactive species

Glen M Borchert,Brian L Gilmore,Ryan M Spengler,Yi Xing,William Lanier,Debashish Bhattacharya,Beverly L Davidson
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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