AB166912

Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11244]

RabMAb
Recombinant
각 태그의 뜻

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(3 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal Dynein intermediate chain 1/DNAI1 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 3 publications.

1 이미지

Unknown

Western blot - Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11244] (AB166912)

All lanes:

Western blot - Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11244] (ab166912) at 1/1000 dilution

Lane 1:

Human fetal lung tissue lysate at 10 µg

Lane 2:

Rat testis tissue lysate at 10 µg

Lane 3:

Mouse testis tissue lysate at 10 µg

Lane 4:

Human testis tissue lysate at 10 µg

Predicted band size: 79 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR11244

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Dynein intermediate chain 1 also known as DNAI1 is a component of the cytoplasmic dynein complex. Mechanically this protein serves as an adaptor or linker within the larger dynein motor protein complex essential for intracellular transport. Its molecular mass is approximately 74 kDa. DNAI1 is expressed in a variety of tissues with higher expression observed in tissues involved in ciliary function. This protein is important for mediating cargo transport along microtubules contributing to cellular functions such as mitosis endocytosis and organelle positioning.

Biological function summary

Dynein intermediate chain 1 participates in key cellular processes linked to the movement of cilia and flagella. DNAI1 is an integral part of the axonemal dynein complex found in motile cilia. This complex enables the conversion of chemical energy from ATP into mechanical work driving the motion of these hair-like structures. Efficient cilia function relies on the coordinated action of axonemal dyneins enabling the clearance of mucus in respiratory pathways and movement of sperm in reproductive tracts.

Pathways

DNAI1 plays a role in the intraflagellar transport pathway important for building and maintaining cilia. Additionally DNAI1 is involved in the respiratory electron transport chain through its contribution to ciliary movement. The protein interacts closely with dynein heavy chain and dynein light chain proteins within these pathways ensuring the effective transport and movement of cellular components.

Defects in dynein intermediate chain 1 are linked to primary ciliary dyskinesia a genetic disorder affecting ciliary function. This disorder results in chronic respiratory tract infections and reduced fertility due to impaired ciliary motion. DNAI1 mutations can also connect to other ciliary dysfunctions impacting proteins like DNAH5 and DNAH11 which work alongside DNAI1 in the motility of cilia and flagella.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Part of the dynein complex of respiratory cilia.

See full target information DNAI1

대체 명칭 보기

Dynein axonemal intermediate chain 1, Axonemal dynein intermediate chain 1, DNAI1

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Proceedings of the National Academy of Sciences of the United States of America 122:e2421915122 PubMed40294271

2025

Inhaled mRNA therapy for treatment of primary ciliary dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Mirko Hennig,Rumpa B Bhattacharjee,Ishita Agarwal,Ali Alfaifi,Jade E Casillas,Sofia Chavez,Daniella Ishimaru,David Liston,Sakya Mohapatra,Touhidul Molla,Suyog Pathare,Maninder S Sidhu,Peng Wang,Zechen Wang,T Noelle Lombana,Vladimir G Kharitonov,Jessica A Couch,David J Lockhart,Brandon A Wustman

CNS neuroscience & therapeutics 30:e14573 PubMed38421101

2024

HDAC9-mediated calmodulin deacetylation induces memory impairment in Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Hai-Long Zhang,Shufen Hu,Pin Yang,Han-Chun Long,Quan-Hong Ma,Dong-Min Yin,Guang-Yin Xu

International journal of molecular sciences 22: PubMed34445527

2021

Identification and Classification of Novel Genetic Variants: En Route to the Diagnosis of Primary Ciliary Dyskinesia.

Applications

Unspecified application

Species

Unspecified reactive species

Nina Stevanovic,Anita Skakic,Predrag Minic,Aleksandar Sovtic,Maja Stojiljkovic,Sonja Pavlovic,Marina Andjelkovic

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11244]

Western blot - Anti-Dynein intermediate chain 1/DNAI1 antibody [EPR11244] (AB166912)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (3)

Product promise