AB244440

Anti-Dystonin/BPA antibody

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Rabbit Polyclonal Dystonin/BPA antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human DST aa 2600 to C-terminus.

대체 명칭 보기

BP230, BP240, BPAG1, DMH, DT, KIAA0728, DST, Dystonin, 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, Bullous pemphigoid antigen 1, Dystonia musculorum protein, Hemidesmosomal plaque protein, BPA, Bullous pemphigoid antigen

5 이미지

Immunocytochemistry/ Immunofluorescence - Anti-Dystonin/BPA antibody (AB244440)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Dystonin/BPA antibody (AB244440)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for Dystonin/BPA (green) using ab244440 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human cerebellum tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human prostate tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human kidney tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Formalin-fixed, paraffin-embedded human tonsil tissue stained for Dystonin/BPA with ab244440 at a 1/50 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human DST aa 2600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q03001

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Dystonin also known as BPA (Bullous Pemphigoid Antigen) is a large protein with a molecular mass of approximately 800 kDa. This versatile protein plays a mechanical role by providing structural integrity to cells particularly within tissues that experience mechanical stress. Dystonin locates mainly in the cytoskeleton-associated regions of muscle and neural cells where it connects cytoskeletal components to membrane complexes. The presence of dystonin in these areas indicates its function in maintaining tissue cohesion and stability under stress.

Biological function summary

Dystonin acts as a cytoskeletal linker that maintains cellular architecture by directly linking intermediate filaments to the actin and microtubule networks. As part of this structural network dystonin forms complexes with other proteins to stabilize cell junctions and muscle fibers. In neural tissues it plays an important role in maintaining the integrity of axons essential for proper nerve function. Dystonin ensures cells retain their shape and positioning which is necessary for regular cellular functions and signal transmissions in these tissues.

Pathways

Dystonin interacts with multiple structural proteins in the cytoskeletal pathway such as keratins and microtubule-associated proteins. The linkage function of dystonin integrates it into the hemidesmosomal pathway which is vital for epithelial cell adhesion. Dystonin works along with other proteins like integrins and plectin which also engage in these pathways promoting cellular adhesion and resilience against mechanical stress.

Mutations or deficiencies in dystonin link to diseases like bullous pemphigoid and Hereditary Sensory and Autonomic Neuropathy Type VI (HSAN VI). Bullous pemphigoid is an autoimmune disorder characterized by blistering of the skin due to compromised cell adhesion. The lack of functional dystonin in HSAN VI leads to nerve degradation highlighting its role in neural maintenance. Proteins like integrins are also implicated in these conditions emphasizing the importance of dystonin-related pathways in maintaining cell adhesion and nerve integrity.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Cytoskeletal linker protein. Acts as an integrator of intermediate filaments, actin and microtubule cytoskeleton networks. Required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. The proteins may self-aggregate to form filaments or a two-dimensional mesh. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Mediates docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport through its interaction with TMEM108 and DCTN1 (By similarity).. Isoform 3. Plays a structural role in the assembly of hemidesmosomes of epithelial cells; anchors keratin-containing intermediate filaments to the inner plaque of hemidesmosomes. Required for the regulation of keratinocyte polarity and motility; mediates integrin ITGB4 regulation of RAC1 activity.. Isoform 6. Required for bundling actin filaments around the nucleus.. Isoform 7. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport.

See full target information DST

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Theranostics 15:6516-6533 PubMed40521210

2025

Loss of in Pancreatic Adenocarcinoma Reversed the Tumor-Promoting Effects of a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Sang Myung Woo,Ho Lee,Joon Hee Kang,Mingyu Kang,Wonyoung Choi,Sung Hoon Sim,Jung Won Chun,Nayoung Han,Kyung-Hee Kim,Woojin Ham,Woosol Hong,Chaeyoung Kim,Jeong Hwan Park,Dawool Han,Jong In Yook,Woo Jin Lee,Soo-Youl Kim

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Dystonin/BPA antibody

Immunocytochemistry/ Immunofluorescence - Anti-Dystonin/BPA antibody (AB244440)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Dystonin/BPA antibody (AB244440)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise