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AB16127

Anti-EBNA 3B antibody

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(2 제품이 사용된 논문 )

Sheep Polyclonal EBNA4 antibody. Suitable for ICC, ELISA, Dot, WB, IHC-P and reacts with Epstein-Barr virus samples. Cited in 2 publications.

대체 명칭 보기

BERF2A-BERF2B, EBNA4, Epstein-Barr nuclear antigen 4, EBNA-4, EBV nuclear antigen 4, Epstein-Barr nuclear antigen 3B, EBNA-3B, EBV nuclear antigen 3B

주요 정보

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Epstein-Barr virus

Applications

Dot, IHC-P, WB, ELISA, ICC

applications

Specificity

This antibody is specific for the Epstein Barr Virus Nuclear Antigen 3B.

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보완 제품

Primary Antibodies

AB90543

Anti-EBNA2 antibody [PE2]

Western blot - Anti-EBNA2 antibody [PE2] (AB90543)

  • 5
  • 2
Primary Antibodies

AB16126

Anti-EBNA 3A antibody

Western blot - Anti-EBNA 3A antibody (AB16126)

  • 4
  • 1
Primary Antibodies

AB16128

Anti-EBNA 3C antibody

  • 3
  • 1
Primary Antibodies

AB78113

Anti-EBV Latent Membrane Protein 1 antibody [CS 1-4]

  • 4
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "Dot" : {"fullname" : "Dot Blot", "shortname":"Dot"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry paraffin embedded sections", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Epstein-Barr virus": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "<p></p>", "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "Dot-species-checked": "guaranteed", "Dot-species-dilution-info": "", "Dot-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Precipitation Ammonium Sulphate
Purification 관련 사항
Purified by ammonium sulfate precipitationThis antibody is provided as a 0.2µm sterile filtered solution.
보관 버퍼
Preservative: 0.08% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The Epstein-Barr nuclear antigen 3B often referred to as EBNA 3B is a protein expressed by the Epstein-Barr virus (EBV). This protein is encoded within the EBV genome and shows an approximate molecular weight of 115 kDa. EBNA 3B is mainly expressed in EBV-infected B cells and plays a role in modulating the viral latent phase. It acts as a transcriptional regulator influencing the expression of both viral and host genes. Researchers also know the target by its role in latency and cellular transformation distinguishing it from other EBNA proteins.
Biological function summary

EBNA 3B contributes to the persistence of the virus in the host by modulating immune responses. It belongs to the EBNA 3 family which includes EBNA 3A and EBNA 3C forming a complex important for proper function. EBNA 3B modifies the host's cell cycle control and apoptosis aiding to maintain the viral latency essential for EBV survival and replication. This manipulation of the host cell environment ensures EBV evasion from immune system detection solidifying its role in persistent infection.

Pathways

EBNA 3B significantly influences the cell cycle and apoptosis pathways. It interacts with other EBNA proteins such as EBNA 2 and EBNA-LP in the Notch signaling pathway which plays an essential role in cell fate determination and immune response regulation. Through the modulation of these pathways EBNA 3B helps facilitate the long-term survival and proliferation of infected B cells. It supports a balance between viral latency and the risk of oncogenic transformation indicative of its strategic role in viral pathobiology.

EBNA 3B shows associations with lymphoproliferative disorders and certain types of cancers such as Burkitt's lymphoma. The protein establishes connections with other EBNA components like EBNA 1 and EBNA 2 which contribute to the oncogenic potential of EBV. These interactions can result in the deregulation of cellular growth and differentiation pathways promoting abnormal cell proliferation. Studies aim to better understand EBNA 3B's involvement in these conditions as targeting EBNA proteins holds therapeutic potential in EBV-related malignancies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May be involved in transcriptional regulation of both viral and cellular genes by interacting with the host DNA-binding protein RBPJ.
See full target information EBNA4
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PLoS pathogens 21:e1013410 PubMed40773523

2025

E2F1 suppresses Epstein-Barr virus lytic reactivation through cellular and viral transcriptional networks.

Applications

Unspecified application

Species

Unspecified reactive species

Joyanta Biswas,Sk Asif Ali,Samaresh Malik,Subhadeep Nag,Piyali Mukherjee,Abhik Saha

PLoS pathogens 16:e1008105 PubMed32092124

2020

Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Chandrima Gain,Samaresh Malik,Shaoni Bhattacharjee,Arijit Ghosh,Erle S Robertson,Benu Brata Das,Abhik Saha
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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