AB234710

Anti-ECEL1 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal ECEL1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ECEL1 aa 400-800.

대체 명칭 보기

XCE, UNQ2431/PRO4991, ECEL1, Endothelin-converting enzyme-like 1, Xce protein

4 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECEL1 antibody (AB234710)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECEL1 antibody (AB234710)

Paraffin-embedded human kidney tissue stained for ECEL1 using ab234710 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECEL1 antibody (AB234710)

Paraffin-embedded human cervical cancer tissue stained for ECEL1 using ab234710 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-ECEL1 antibody (AB234710)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ECEL1 antibody (AB234710)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for ECEL1 (green) using ab234710 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor^® 488-conjugated Goat Anti-Rabbit IgG (H+L).

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ECEL1 antibody (AB234710)

HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for ECEL1 (green) using ab234710 at 1/100 dilution in ICC/IF. Secondary antibody is Alexa Fluor^® 488-conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ECEL1 aa 400-800. The exact immunogen used to generate this antibody is proprietary information.

O95672

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ECEL1 also known as endothelin-converting enzyme-like 1 or puromycin-sensitive aminopeptidase is a zinc-dependent metalloprotease with a molecular mass of about 85 kDa. This enzyme primarily expresses in the nervous system indicating a unique role in neuronal function. ECEL1 localizes in the endoplasmic reticulum and Golgi apparatus participating in processing neuropeptides although its full range of substrates is not completely defined.

Biological function summary

ECEL1 functions to modulate neuropeptide activity by cleaving specific peptide bonds acting as a critical regulator in the nervous system. It does not appear to form part of a larger protein complex but interacts closely with other enzymes involved in neuropeptide processing. Through its enzymatic activity ECEL1 plays a role in maintaining neurotransmitter balance thereby influencing nervous system communication.

Pathways

ECEL1 participates in neuropeptide and signaling pathways such as the endothelin-signaling pathway. ECEL1's activity impacts the function and expression of proteins like endothelin and other neuropeptides involved in vasoconstriction and neurotransmission. ECEL1 works alongside enzymes like neprilysin cooperating in peptide degradation and activation processes within these pathways.

ECEL1 has association with musculoskeletal and neurological conditions including congenital contractural arachnodactyly. Mutations in ECEL1 can lead to disruptions in neuropeptide processing contributing to developmental abnormalities. Moreover studies suggest an involvement of ECEL1 with proteins such as those related to collagen metabolism linking it to connective tissue disorders and highlighting its role in proper muscular and neuronal development.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides.

See full target information ECEL1

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell stem cell 30:677-688.e5 PubMed37019105

2023

Generation of ventralized human thalamic organoids with thalamic reticular nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Ferdi Ridvan Kiral,Bilal Cakir,Yoshiaki Tanaka,Jonghun Kim,Woo Sub Yang,Fabien Wehbe,Young-Jin Kang,Mei Zhong,Gizem Sancer,Sang-Hun Lee,Yangfei Xiang,In-Hyun Park

Cell reports 40:111086 PubMed35858576

2022

Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus.

Applications

Unspecified application

Species

Unspecified reactive species

Chao Gao,Jinge Gu,Hong Zhang,Kai Jiang,Linlin Tang,Ren Liu,Li Zhang,Pengfei Zhang,Cong Liu,Bin Dai,Jie Song

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ECEL1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECEL1 antibody (AB234710)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECEL1 antibody (AB234710)

Immunocytochemistry/ Immunofluorescence - Anti-ECEL1 antibody (AB234710)

Immunocytochemistry/ Immunofluorescence - Anti-ECEL1 antibody (AB234710)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise