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AB244451

Anti-ECM antibody

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Rabbit Polyclonal ECM antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMRN1 aa 650 to C-terminus.

대체 명칭 보기

ECM, EMILIN4, GPIA*, MMRN, MMRN1, Multimerin-1, EMILIN-4, Elastin microfibril interface located protein 4, Endothelial cell multimerin, Elastin microfibril interfacer 4

3 이미지
Immunocytochemistry/ Immunofluorescence - Anti-ECM antibody (AB244451)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ECM antibody (AB244451)

PFA-fixed, Triton X-100 permeabilized HUVEC TERT2 cells stained for ECM (green) using ab244451 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)

Paraffin-embedded human gallbladder tissue stained for ECM using ab244451 at 1/500 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ECM antibody (AB244451)

Paraffin-embedded human skeletal muscle tissue stained for ECM using ab244451 at 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MMRN1 aa 650 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q13201

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보완 제품

Primary Antibodies

AB138492

Anti-Collagen I antibody [EPR7785]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)

  • 4
  • 37
Primary Antibodies

AB268020

Anti-Fibronectin antibody [EPR23110-46]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibronectin antibody [EPR23110-46] (AB268020)

  • 4
  • 5
Primary Antibodies

AB7778

Anti-Collagen III antibody

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Collagen III antibody (AB7778)

  • 4
  • 24
Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The extracellular matrix (ECM) constitutes a complex network of macromolecules such as proteins and glycoproteins including the key structural proteins like collagen elastin fibronectin and laminin. It provides structural support to cells and tissues and plays a role in signal transmission across the cellular environment. The ECM does not have a singular mass due to its diverse composition but is expressed throughout different tissues in the body. Its complexity and vast distribution are essential for maintaining tissue architecture and function.
Biological function summary

The extracellular matrix coordinates cellular functions by mediating mechanical and biochemical signals influencing cellular processes such as adhesion differentiation and migration. The ECM is an essential component of the matrix receptor complex interacting dynamically with cell-surface receptors like integrins. These interactions are important to tissue remodeling and repair allowing tissues to maintain homeostasis and respond to external stresses.

Pathways

The extracellular matrix participates in significant biological pathways like the integrin signaling pathway and the Wnt signaling pathway. These pathways link ECM to various cellular responses affecting processes such as cell migration proliferation and survival. Integrin proteins for example bind to ECM proteins transmitting signals that can regulate gene expression and determine cell fate. Disruption in these pathways has implications for developmental processes and disease states.

The extracellular matrix plays a role in conditions such as fibrosis and cancer. Alterations in ECM components or remodelling can lead to fibrotic diseases where excessive ECM deposition affects tissue function. In cancer ECM changes can influence tumor progression and metastasis. Matrix metalloproteinases (MMPs) a group of enzymes breaking down ECM proteins connect ECM to these pathological states altering tissue integrity and facilitating disease progression. Understanding ECM dynamics is therefore essential for developing therapeutic strategies against these disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein.
See full target information MMRN1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of thoracic disease 16:8363-8378 PubMed39831245

2025

Endoplasmic reticulum stress-MMRN1 positive feedback contributes to cisplatin resistance in small cell lung cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Mingxin Liu,Peihong Hu,Bo Tang,Qi Yang,Run Xiang,Yiqiang Liu,Juan Li,Binghuo Wu,Hong Wu,Bo Tian,Chuan Xu,Qiang Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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