JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB125233

Anti-EDA antibody

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal EDA antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human EDA.

대체 명칭 보기

ED1, EDA2, EDA, Ectodysplasin-A, Ectodermal dysplasia protein, EDA protein

1 이미지
Western blot - Anti-EDA antibody (AB125233)
  • WB

Unknown

Western blot - Anti-EDA antibody (AB125233)

All lanes:

Western blot - Anti-EDA antibody (ab125233) at 1 µg/mL

All lanes:

SW620 Cell Lysate

Predicted band size: 41 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human EDA. The exact immunogen used to generate this antibody is proprietary information.

Q92838

style
left-column

대체품

Primary Antibodies

AB198022

Anti-EDA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDA antibody (AB198022)

  • 0
  • 0

보완 제품

Primary Antibodies

AB32419

Anti-Fibronectin antibody [F1]

20ul selling size|RabMAb|Recombinant|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Fibronectin antibody [F1] (AB32419)

  • 5
  • 7
Sample Prep & Detection Kits

AB236553

Alexa Fluor® 488 Conjugation Kit (Fast) - Lightning-Link®

Immunocytochemistry - Alexa Fluor® 488 Conjugation Kit (Fast) - Lightning-Link® (AB236553)

  • 5
  • 5
Primary Antibodies

AB138492

Anti-Collagen I antibody [EPR7785]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Frozen sections) - Anti-Collagen I antibody [EPR7785] (AB138492)

  • 4
  • 37
Primary Antibodies

AB211438

Anti-CRLF1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF1 antibody (AB211438)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

EDA also known as Ectodysplasin A is a protein encoded by the EDA gene. It is a member of the tumor necrosis factor (TNF) family and is expressed in epithelial cells. The molecular mass of EDA is approximately 47 kDa. EDA plays a mechanical role in signaling processes that are important for developmental pathways. Its expression is observed in tissues like skin hair follicles and some glandular cells where it contributes to cellular communication.
Biological function summary

Ectodysplasin A influences the development and differentiation of epithelial tissues. It plays a role in the formation of hair shafts sweat glands and other ectodermal structures. EDA operates as part of a signaling complex influencing cell fate decisions through binding to its receptor EDA receptor (EDAR). This interaction initiates processes for the development and maintenance of these structures impacting cell proliferation and differentiation.

Pathways

Not only does EDA interact in the TNF signaling pathway it also engages in the NF-kB pathway. The NF-kB pathway initiates transcription of genes responsible for cell survival and inflammatory responses. EDA interaction with EDAR also involves signaling pathways intersecting with NF-kB leading to activation of downstream proteins like TRAF6 and NEMO. These proteins orchestrate cell proliferation and apoptotic regulation confirming EDA's role in strategic developmental and signaling pathways.

Abnormal function or mutations in EDA link to conditions such as X-linked hypohidrotic ectodermal dysplasia (XLHED) and immune system irregularities. XLHED occurs due to EDA gene mutations leading to missing or improperly developed ectodermal structures like hair and teeth. EDA's association with XLHED connects it to EDAR and down to other proteins such as NF-kB indicating the broader genetic mutations' impact on downstream signaling which results in specific phenotype alterations seen in the disorder.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Cytokine which is involved in epithelial-mesenchymal signaling during morphogenesis of ectodermal organs. Functions as a ligand activating the DEATH-domain containing receptors EDAR and EDA2R (PubMed : 11039935, PubMed : 27144394, PubMed : 34582123, PubMed : 8696334). May also play a role in cell adhesion (By similarity).. Isoform 1. Binds only to the receptor EDAR, while isoform 3 binds exclusively to the receptor EDA2R.. Isoform 3. Binds only to the receptor EDA2R.
See full target information EDA
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 8:e2103079 PubMed34569165

2021

Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyan Sun,Jiangbing Xiang,Runkai Chen,Zhijun Geng,Lintao Wang,Yiqiong Liu,Shuaifei Ji,Huating Chen,Yan Li,Cuiping Zhang,Peng Liu,Tao Yue,Lei Dong,Xiaobing Fu

Molecular medicine reports 17:4688-4694 PubMed29344666

2018

Let-7b regulates alpaca hair growth by downregulating ectodysplasin A.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Liu,Shu Niu,Xiao-Rui Cao,Jia-Qi Cheng,Shu-Yuan Gao,Xiu-Ju Yu,Hai-Dong Wang,Chang-Sheng Dong,Xiao-Yan He
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com