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AB235106

Anti-EDAR antibody

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Rabbit Polyclonal EDAR antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human EDAR aa 1-200.

대체 명칭 보기

DL, EDAR, Tumor necrosis factor receptor superfamily member EDAR, Anhidrotic ectodysplasin receptor 1, Downless homolog, EDA-A1 receptor, Ectodermal dysplasia receptor, Ectodysplasin-A receptor

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (AB235106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (AB235106)

Paraffin-embedded human bladder cancer tissue stained for EDAR using ab235106 at 1/500 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized tissue using an HRP conjugated SP system.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (AB235106)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EDAR antibody (AB235106)

Paraffin-embedded human liver cancer tissue stained for EDAR using ab235106 at 1/500 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized tissue using an HRP conjugated SP system.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human EDAR aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9UNE0

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대체품

Primary Antibodies

AB245684

Anti-EDAR antibody [EDAR12]

Immunocytochemistry/ Immunofluorescence - Anti-EDAR antibody [EDAR12] (AB245684)

  • 0
  • 0

보완 제품

Primary Antibodies

AB125233

Anti-EDA antibody

Western blot - Anti-EDA antibody (AB125233)

  • 0
  • 0
Primary Antibodies

AB190085

Anti-ZO1 tight junction protein antibody - C-terminal

Western blot - Anti-ZO1 tight junction protein antibody - C-terminal (AB190085)

  • 4
  • 28
Primary Antibodies

AB184337

Anti-Lhx2/LH2 antibody [EPR20449]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Lhx2/LH2 antibody [EPR20449] (AB184337)

  • 5
  • 6
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/300 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The ectodysplasin A receptor also known as EDAR is a transmembrane protein involved in various developmental processes. It has a molecular mass of approximately 63 kDa. You can find EDAR expression in tissues such as the skin hair follicles and teeth. As a member of the tumor necrosis factor receptor (TNFR) family EDAR plays an important mechanical role by binding ectodysplasin A ligand (EDA) which initiates downstream signals important for developmental pathways.
Biological function summary

The interaction between EDAR and its ligand EDA influences morphogenesis of ectodermal-derived structures. This receptor-ligand binding is integral to the EDAR/NF-kappaB signaling complex. It affects processes such as the formation of hair follicles sweat glands and teeth. The receptor facilitates cell communication necessary for the proper development of these structures ensuring the correct activation of related signaling pathways.

Pathways

EDAR functions within the NF-kappaB and Wnt signaling pathways. These pathways regulate cellular differentiation and proliferation. The receptor collaborates with adapter proteins such as EDARADD to effectively transmit signals downstream. Furthermore it shares significant relationships with other TNF receptor family members highlighting the importance of signaling specificity and coordination within these biological pathways.

Mutations in the EDAR gene associate with ectodermal dysplasia a genetic disorder affecting hair teeth and sweat glands. Additionally EDAR influences the development of hypohidrotic ectodermal dysplasia (HED). The receptor's link with EDA and other TNFR family members highlights the complex genetic interactions contributing to these conditions. Understanding these relationships provides insights into targeted therapeutic strategies addressing developmental abnormalities.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Receptor for EDA isoform A1, but not for EDA isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote caspase-independent cell death.
See full target information EDAR
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular biology of the cell 35:ar133 PubMed39196658

2024

mDia2 is an important mediator of MRTF-A-dependent regulation of breast cancer cell migration.

Applications

Unspecified application

Species

Unspecified reactive species

Ian Eder,Virginia Yu,Jacob Antonello,Fangyuan Chen,David Gau,Pooja Chawla,Marion Joy,Peter C Lucas,David Boone,Adrian V Lee,Partha Roy
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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