JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB108399

Anti-EGR2 antibody [EPR4004]

4

(3 리뷰들)

|

(23 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal EGR2 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 23 publications.

대체 명칭 보기

KROX20, EGR2, E3 SUMO-protein ligase EGR2, AT591, E3 SUMO-protein transferase ERG2, Early growth response protein 2, Zinc finger protein Krox-20, EGR-2

1 이미지
Western blot - Anti-EGR2 antibody [EPR4004] (AB108399)
  • WB

Unknown

Western blot - Anti-EGR2 antibody [EPR4004] (AB108399)

All lanes:

Western blot - Anti-EGR2 antibody [EPR4004] (ab108399) at 1/1000 dilution

Lane 1:

LnCaP cell lysate at 10 µg

Lane 2:

HepG2 cell lysate at 10 µg

Lane 3:

MCF7 cell lysate at 10 µg

Lane 4:

SH SY5Y cell lysate at 10 µg

Predicted band size: 50 kDa

false

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-EGR2 antibody [EPR4004] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR4004

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

대체품

Primary Antibodies

AB43020

Anti-EGR2 antibody

  • 4
  • 2
Primary Antibodies

AB282791

PE Anti-EGR2 antibody [EPR23228-40]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - PE Anti-EGR2 antibody [EPR23228-40] (AB282791)

  • 0
  • 0
Primary Antibodies

AB245228

Anti-EGR2 antibody [EPR23228-40]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Flow Cytometry (Intracellular) - Anti-EGR2 antibody [EPR23228-40] (AB245228)

  • 0
  • 0
Primary Antibodies

AB270755

Anti-EGR2 antibody [EPR23228-40] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-EGR2 antibody [EPR23228-40] - BSA and Azide free (AB270755)

  • 0
  • 0
Primary Antibodies

AB156765

Anti-EGR2 antibody [OTI1F10]

Immunocytochemistry/ Immunofluorescence - Anti-EGR2 antibody [OTI1F10] (AB156765)

  • 0
  • 0
Primary Antibodies

AB63943

Anti-EGR2 antibody

Western blot - Anti-EGR2 antibody (AB63943)

  • 0
  • 1
Primary Antibodies

AB232695

Anti-EGR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EGR2 antibody (AB232695)

  • 0
  • 0

보완 제품

Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB115777

Anti-beta Actin antibody [SP124] - Cytoskeleton Marker

20ul selling size|RabMAb|Lab Essentials|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Actin antibody [SP124] - Cytoskeleton Marker (AB115777)

  • 4
  • 1
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
style
left-column

제품 세부 정보

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Stable for 12 months at -20°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

EGR2 also known as early growth response 2 or KROX20 refers to a transcription factor with a mass of approximately 53 kDa. This protein plays a significant role in gene expression and regulates various genes involved in cellular growth and differentiation. EGR2 is expressed in various tissues with notable presence in the nervous system particularly within Schwann cells and the developing vertebrate nervous system. It can also be found in immune system cells including T and B cells.
Biological function summary

EGR2 influences the development and function of the peripheral nervous system contributing to processes like nerve myelination. It acts as a transcriptional regulator controlling the expression of genes that are essential for the maintenance of myelin sheaths around nerves. While EGR2 does not directly form part of a protein complex its role as a transcription factor allows it to interact with many other proteins to exert its regulatory functions.

Pathways

EGR2 participates in cellular pathways such as the MAPK/ERK signaling pathway and the immune response pathway. In the MAPK/ERK pathway EGR2 interacts with proteins like ERK1/2 to regulate cell growth and differentiation. In immune response pathways EGR2 modulates the differentiation of T cells impacting immune homeostasis and function by influencing gene expression pertinent to immune regulation.

Mutations or dysregulation of EGR2 can relate to Charcot-Marie-Tooth disease type 1 a peripheral nerve disorder. This neuropathy impacts myelin production where alterations in EGR2 play a role alongside proteins like PMP22 which are also affected in the disorder. Additionally EGR2 expression irregularities have been studied in connection with systemic lupus erythematosus in which immune cell regulation becomes impaired affecting proteins involved in immune signaling.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Sequence-specific DNA-binding transcription factor (PubMed : 17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity).. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity.
See full target information EGR2
style
left-column

제품이 사용된 논문 (23)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular and cellular biology 42:e0055921 PubMed35708320

2022

Aberrant Neuregulin 1/ErbB Signaling in Charcot-Marie-Tooth Type 4D Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Ting Jiang,Yu-Hui Chen,Jie-Hong Huang,Wei-Fang Tong,Ling-Jing Jin,Li-Xi Li

Cancers 14: PubMed35565457

2022

Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins.

Applications

Unspecified application

Species

Unspecified reactive species

Charlie Buchou,Karine Laud-Duval,Wietske van der Ent,Sandrine Grossetête,Sakina Zaidi,Géraldine Gentric,Maxime Corbé,Kévin Müller,Elaine Del Nery,Didier Surdez,Olivier Delattre

Diabetes 71:394-411 PubMed35029277

2022

Obesity-Induced miR-455 Upregulation Promotes Adaptive Pancreatic β-Cell Proliferation Through the CPEB1/CDKN1B Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Qianxing Hu,Jinming Mu,Yuhong Liu,Yue Yang,Yue Liu,Yi Pan,Yanfeng Zhang,Ling Li,Dechen Liu,Jianqiu Chen,Fangfang Zhang,Liang Jin

Journal of Ayurveda and integrative medicine 13:100501 PubMed34799209

2021

Molecular insights for an anti-osteoporotic properties of Litsea glutinosa on Saos-2 cells: An in-vitro approach.

Applications

Unspecified application

Species

Unspecified reactive species

Hitarth Changani,Pragna Parikh

F1000Research 10:917 PubMed36071890

2021

Preventive effect of on M1/M2 ratio, reducing risk of endothelial dysfunction in cigarette smoked Wistars.

Applications

Unspecified application

Species

Unspecified reactive species

Meity Ardiana,Eka Utami,Budi Pikir,Anwar Santoso

Cell & bioscience 11:84 PubMed33980319

2021

The YAP/HIF-1α/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zhou,Ning Zhang,Wei Zhang,Caiju Lu,Fei Xu

Frontiers in cell and developmental biology 8:579236 PubMed33505958

2021

Extracellular Vesicle-Derived microRNA-410 From Mesenchymal Stem Cells Protects Against Neonatal Hypoxia-Ischemia Brain Damage Through an HDAC1-Dependent EGR2/Bcl2 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jun Han,Si Yang,Xiaosheng Hao,Bo Zhang,Hongbo Zhang,Cuijuan Xin,Yunpeng Hao

Communications biology 3:716 PubMed33247229

2020

Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaona Feng,Yasunori Takayama,Nobuhiko Ohno,Hirosato Kanda,Yi Dai,Takaaki Sokabe,Makoto Tominaga

Nutrients 12: PubMed33238473

2020

Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Wanda M Snow,Chris Cadonic,Claudia Cortes-Perez,Aida Adlimoghaddam,Subir K Roy Chowdhury,Ella Thomson,Adama Anozie,Michael J Bernstein,Kathleen Gough,Paul Fernyhough,Miyoung Suh,Benedict C Albensi

PloS one 15:e0242137 PubMed33180885

2020

Soluble dimeric prion protein ligand activates Adgrg6 receptor but does not rescue early signs of demyelination in PrP-deficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Anna Henzi,Assunta Senatore,Asvin K K Lakkaraju,Claudia Scheckel,Jonas Mühle,Regina Reimann,Silvia Sorce,Gebhard Schertler,Klaus V Toyka,Adriano Aguzzi
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com