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AB74941

Anti-ELOVL1/SSC1 antibody

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Rabbit Polyclonal ELOVL1/SSC1 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ELOVL1.
1 이미지
Western blot - Anti-ELOVL1/SSC1 antibody (AB74941)
  • WB

Unknown

Western blot - Anti-ELOVL1/SSC1 antibody (AB74941)

All lanes:

Western blot - Anti-ELOVL1/SSC1 antibody (ab74941) at 1/500 dilution

Lane 1:

Extracts from HepG2 cells at 15 µg

Lane 2:

Extracts from Jurkat cells at 15 µg

Lane 3:

Extracts from Jurkat cells at 15 µg with immunizing peptide

Predicted band size: 33 kDa

Observed band size: 36 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ELOVL1. The exact immunogen used to generate this antibody is proprietary information.

Q9BW60

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대체품

Primary Antibodies

AB204489

Anti-ELOVL1/SSC1 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

  • 5
  • 1
Primary Antibodies

AB230634

Anti-ELOVL1/SSC1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody (AB230634)

  • 0
  • 0

보완 제품

Primary Antibodies

AB69857

Anti-ELOVL6/LCE antibody

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL6/LCE antibody (AB69857)

  • 0
  • 0
Primary Antibodies

AB205535

Anti-ELOVL5 antibody [EPR17151]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL5 antibody [EPR17151] (AB205535)

  • 0
  • 0
Primary Antibodies

AB313881

Anti-SREBP1 antibody [EPR27079-194]

20ul selling size|KO Validated|RabMAb|Recombinant

Western blot - Anti-SREBP1 antibody [EPR27079-194] (AB313881)

  • 0
  • 0
Primary Antibodies

AB30682

Anti-SREBP2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SREBP2 antibody (AB30682)

  • 4
  • 12
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ELOVL1 also known as SSC1 functions as an important enzyme involved in the elongation of long-chain fatty acids. It catalyzes the first and rate-limiting step in the fatty acid elongation cycle which involves the condensation of long-chain acyl-CoAs with malonyl-CoA. ELOVL1 has a molecular mass of approximately 31 kDa. You can find it expressed in various tissues but particularly enriched in skin brain and liver tissues. Its expression is not uniformly distributed as it varies depending on cell type and physiology.
Biological function summary

ELOVL1 is responsible for the biosynthesis of very long-chain fatty acids (VLCFAs) which are important components of cell membranes and lipids. ELOVL1 is not known as part of a larger protein complex but contributes significantly to cellular lipid metabolism. VLCFAs are essential to maintaining the integrity and functionality of cell structures and signaling processes supporting various physiological roles within the body. Its regulation affects the homeostasis of lipids impacting numerous cellular processes.

Pathways

ELOVL1 plays an important role in lipid metabolic pathways including the fatty acid elongation and ceramide biosynthesis pathways. It interacts with other enzymes and proteins such as ELOVL4 and ceramide synthases to ensure the production of diverse lipid molecules required for cell survival and proliferation. These pathways facilitate the synthesis and modification of lipids accommodating the needs of dynamic cellular environments.

Faulty ELOVL1 function links with conditions like ichthyosis and neurological disorders. Deficiencies or mutations in ELOVL1 can disrupt the normal production of VLCFAs leading to skin abnormalities and neurological impairments. The protein's association with other lipid metabolism-related proteins like ABCD1 in X-linked adrenoleukodystrophy highlights the broader significance of ELOVL1 in maintaining health and preventing disease. Understanding ELOVL1's role and mechanisms can contribute to therapeutic approaches targeting metabolic and neurodegenerative diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed : 29496980, PubMed : 30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22 : 0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24 : 0 and monounsaturated C24 : 1 sphingolipid synthesis (PubMed : 20937905). Indirectly inhibits RPE65 via production of VLCFAs.
See full target information ELOVL1

대체 명칭 보기

SSC1, CGI-88, ELOVL1, Very long chain fatty acid elongase 1, 3-keto acyl-CoA synthase ELOVL1, ELOVL fatty acid elongase 1, Elongation of very long chain fatty acids protein 1, Very long chain 3-ketoacyl-CoA synthase 1, Very long chain 3-oxoacyl-CoA synthase 1, ELOVL FA elongase 1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 16:16440-53 PubMed26204830

2015

Inhibition of Mammalian Target of Rapamycin Complex 1 (mTORC1) Downregulates ELOVL1 Gene Expression and Fatty Acid Synthesis in Goat Fetal Fibroblasts.

Applications

WB

Species

Unspecified reactive species

Weipeng Wang,Qiburi He,Zhixin Guo,Limin Yang,Lili Bao,Wenlei Bao,Xu Zheng,Yanfeng Wang,Zhigang Wang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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