AB204489

Anti-ELOVL1/SSC1 antibody - C-terminal

Name: Anti-ELOVL1/SSC1 antibody - C-terminal
Brand: Abcam Limited
SKU: AB204489
Rating: 5 (1 reviews)

(1 리뷰)

(1 출판물)

Rabbit Polyclonal ELOVL1/SSC1 antibody. C-terminal. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ELOVL1 aa 250 to C-terminus.

대체 명칭 보기

SSC1, CGI-88, ELOVL1, Very long chain fatty acid elongase 1, 3-keto acyl-CoA synthase ELOVL1, ELOVL fatty acid elongase 1, Elongation of very long chain fatty acids protein 1, Very long chain 3-ketoacyl-CoA synthase 1, Very long chain 3-oxoacyl-CoA synthase 1, ELOVL FA elongase 1

5 이미지

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunocytochemical/Immunofluorescent analysis of parafomaldehyde-fixed, triton x-100 permeabilised human cell line U-2OS cells staining ELOVL1/SSC1 with ab204489 at 4μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human skeletal muscle tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human skin tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human kidney tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemical analysis of paraffin-embedded human colon tissue staining ELOVL1/SSC1 with ab204489 at 1/20 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ELOVL1 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BW60

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ELOVL1 also known as SSC1 functions as an important enzyme involved in the elongation of long-chain fatty acids. It catalyzes the first and rate-limiting step in the fatty acid elongation cycle which involves the condensation of long-chain acyl-CoAs with malonyl-CoA. ELOVL1 has a molecular mass of approximately 31 kDa. You can find it expressed in various tissues but particularly enriched in skin brain and liver tissues. Its expression is not uniformly distributed as it varies depending on cell type and physiology.

Biological function summary

ELOVL1 is responsible for the biosynthesis of very long-chain fatty acids (VLCFAs) which are important components of cell membranes and lipids. ELOVL1 is not known as part of a larger protein complex but contributes significantly to cellular lipid metabolism. VLCFAs are essential to maintaining the integrity and functionality of cell structures and signaling processes supporting various physiological roles within the body. Its regulation affects the homeostasis of lipids impacting numerous cellular processes.

Pathways

ELOVL1 plays an important role in lipid metabolic pathways including the fatty acid elongation and ceramide biosynthesis pathways. It interacts with other enzymes and proteins such as ELOVL4 and ceramide synthases to ensure the production of diverse lipid molecules required for cell survival and proliferation. These pathways facilitate the synthesis and modification of lipids accommodating the needs of dynamic cellular environments.

Faulty ELOVL1 function links with conditions like ichthyosis and neurological disorders. Deficiencies or mutations in ELOVL1 can disrupt the normal production of VLCFAs leading to skin abnormalities and neurological impairments. The protein's association with other lipid metabolism-related proteins like ABCD1 in X-linked adrenoleukodystrophy highlights the broader significance of ELOVL1 in maintaining health and preventing disease. Understanding ELOVL1's role and mechanisms can contribute to therapeutic approaches targeting metabolic and neurodegenerative diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle (PubMed : 29496980, PubMed : 30487246). This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated and monounsaturated acyl-CoA substrates, with the highest activity towards C22 : 0 acyl-CoA. May participate in the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24 : 0 and monounsaturated C24 : 1 sphingolipid synthesis (PubMed : 20937905). Indirectly inhibits RPE65 via production of VLCFAs.

See full target information ELOVL1

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Anatomical record (Hoboken, N.J. : 2007) 305:209-221 PubMed34041863

2021

Outer and inner mitochondrial membrane proteins TOMM40 and TIMM50 are intensively concentrated and localized at Purkinje and pyramidal neurons in the New Zealand white rabbit brain.

Applications

Unspecified application

Species

Unspecified reactive species

Sameh M Farouk,Ahmed M Abdellatif,Elsayed Metwally

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ELOVL1/SSC1 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL1/SSC1 antibody - C-terminal (AB204489)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (1)

Product promise