AB69857

Anti-ELOVL6/LCE antibody

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(19 제품이 사용된 논문 )

Rabbit Polyclonal ELOVL6/LCE antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Cited in 19 publications. Immunogen corresponding to Synthetic Peptide within Human ELOVL6.

3 이미지

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL6/LCE antibody (AB69857)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL6/LCE antibody (AB69857)

Immunofluorescence of ELOVL6/LCE in Human Brain cells using ab69857 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL6/LCE antibody (AB69857)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL6/LCE antibody (AB69857)

Immunohistochemistry of ELOVL6/LCE in human brain with ab69857 at 5 μg/ml.

Unknown

Western blot - Anti-ELOVL6/LCE antibody (AB69857)

Lane 1:

Western blot - Anti-ELOVL6/LCE antibody (ab69857) at 1 µg/mL

Lane 2:

Western blot - Anti-ELOVL6/LCE antibody (ab69857) at 2 µg/mL

All lanes:

Human brain tissue lysate at 15 µg

Predicted band size: 31 kDa

Observed band size: 28 kDa

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human ELOVL6. The exact immunogen used to generate this antibody is proprietary information.

Q9H5J4

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1 µg/mL", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ELOVL6 sometimes also known as LCE functions as an enzyme involved in the elongation of long-chain fatty acids. It primarily elongates saturated and monounsaturated fatty acyl-CoAs especially those that are C16:0 and C18:0 contributing to the production of very long-chain fatty acids. This protein has a molecular mass of approximately 29 kilodaltons and exists mainly in the endoplasmic reticulum. ELOVL6 is ubiquitously expressed with notable presence in the liver adipose tissues and brain where it plays significant roles in lipid metabolism.

Biological function summary

This enzyme modifies fatty acids therefore impacting the lipid composition of cellular membranes and lipid droplets. It does not function alone; ELOVL6 works in concert with other enzymes to regulate lipid metabolism impacting energy balance and cellular signaling. The protein influences desaturation and incorporates elongated fatty acids into more complex lipid molecules which are important for membrane fluidity and function as well as hormone signaling.

Pathways

ELOVL6 participates actively in the fatty acid biosynthesis pathway and the lipid metabolic pathway. It works closely with proteins like SCD1 (stearoyl-CoA desaturase 1) enhancing fatty acid desaturation processes. ELOVL6's function in fatty acid elongation is essential for maintaining the fluidity and functionality of lipid bilayers affecting various downstream processes including energy homeostasis and inflammation.

Research links ELOVL6 to metabolic conditions like obesity and non-alcoholic fatty liver disease (NAFLD). The enzyme's role in excessive fatty acid elongation and lipid accumulation can contribute to these disorders. ELOVL6 may interact with proteins such as AMPK (AMP-activated protein kinase) which is involved in metabolic regulation and can influence disease outcomes. These interactions suggest potential therapeutic targets for metabolic diseases where modifying ELOVL6 activity could alter the progression of lipid-related disorders.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16 : 0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18 : 0 and those with low desaturation degree. May participate in the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.

See full target information ELOVL6

대체 명칭 보기

FACE, LCE, ELOVL6, Very long chain fatty acid elongase 6, 3-keto acyl-CoA synthase ELOVL6, ELOVL fatty acid elongase 6, Elongation of very long chain fatty acids protein 6, Fatty acid elongase 2, Fatty acyl-CoA elongase, Long-chain fatty-acyl elongase, Very long chain 3-ketoacyl-CoA synthase 6, Very long chain 3-oxoacyl-CoA synthase 6, ELOVL FA elongase 6, hELO2

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제품이 사용된 논문 (19)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer cell international 24:432 PubMed39726006

2024

Protein kinase CK2 sustains de novo fatty acid synthesis by regulating the expression of SCD-1 in human renal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Barbara Guerra,Kristina Jurcic,Rachelle van der Poel,Samantha Lynn Cousineau,Thomas K Doktor,Laura M Buchwald,Scott E Roffey,Caroline A Lindegaard,Anna Z Ferrer,Mohammad A Siddiqui,Laszlo Gyenis,Brage S Andresen,David W Litchfield

International immunopharmacology 138:112588 PubMed38955031

2024

Alleviation effects of dexmedetomidine on myocardial ischemia/reperfusion injury through fatty acid metabolism pathway via Elovl6.

Applications

Unspecified application

Species

Unspecified reactive species

Haozheng Yuan,Jingying Guo,Congxia Wang,Chunyan Zhang

Cell death & disease 14:182 PubMed36878903

2023

USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC.

Applications

Unspecified application

Species

Unspecified reactive species

Nan Wang,Tianzi Li,Wanyu Liu,Jinhua Lin,Ke Zhang,Zhenhao Li,Yanfei Huang,Yufei Shi,Meilan Xu,Xuekui Liu

International journal of genomics 2023:9708282 PubMed36818393

2023

An Investigation of the Prognostic Role of Genes Related to Lipid Metabolism in Head and Neck Squamous Cell Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Qian,Chenyu Zhou,Keyi Wang,Liuyang Li,Wenhui Xia,Yuan Fan

Archives animal breeding 65:357-370 PubMed36304442

2022

Bta-miR-33a affects gene expression and lipid levels in Chinese Holstein mammary epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Jiang,Ambreen Iqbal,Zhiqian Cui,Haibin Yu,Zhihui Zhao

Animals : an open access journal from MDPI 12: PubMed36077994

2022

A Specific microRNA Targets an Elongase of Very Long Chain Fatty Acids to Regulate Fatty Acid Composition and Mitochondrial Morphology of Skeletal Muscle Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Han Wang,Moran Hu,Zhonghao Shen,Xiaolong Zhou,Songbai Yang,Ke He,Xiangchen Li,Feifei Yan,Ayong Zhao

Toxicology research 11:673-682 PubMed36051666

2022

Tamoxifen induced hepatic steatosis in high-fat feeding rats through SIRT1-Foxo1 suppression and LXR-SREBP1c activation.

Applications

Unspecified application

Species

Unspecified reactive species

Miao Li,Yu Cai,Xi Chen,Luyong Zhang,Zhenzhou Jiang,Qinwei Yu

Nutrients 13: PubMed33374283

2020

Mexican Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet.

Applications

Unspecified application

Species

Unspecified reactive species

Sandra L Romero-Córdoba,Ivan Salido-Guadarrama,María E Meneses,Giulia Cosentino,Marilena V Iorio,Elda Tagliabue,Nimbe Torres,Mónica Sánchez-Tapia,Myrna Bonilla,Ivan Castillo,Beatriz Petlacalco,Armando R Tovar,Daniel Martínez-Carrera

American journal of physiology. Endocrinology and 319:E133-E145 PubMed32459527

2020

Bromocriptine mesylate improves glucose tolerance and disposal in a high-fat-fed canine model.

Applications

Unspecified application

Species

Unspecified reactive species

Mary Courtney Moore,Marta S Smith,Larry L Swift,Anthony H Cincotta,Michael Ezrokhi,Nicholas Cominos,Yahong Zhang,Ben Farmer,Alan D Cherrington

Lipids 55:309-327 PubMed32314395

2020

High Glucose and Liver Fatty Acid Binding Protein Gene Ablation Differentially Impact Whole Body and Liver Phenotype in High-Fat Pair-Fed Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Gregory G Martin,Danilo Landrock,Avery L McIntosh,Sherrelle Milligan,Kerstin K Landrock,Ann B Kier,John Mackie,Friedhelm Schroeder

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ELOVL6/LCE antibody

Immunocytochemistry/ Immunofluorescence - Anti-ELOVL6/LCE antibody (AB69857)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ELOVL6/LCE antibody (AB69857)

Western blot - Anti-ELOVL6/LCE antibody (AB69857)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (19)

Product promise