JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB75190

Anti-EMR2 antibody

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal EMR2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ADGRE2.
1 이미지
Western blot - Anti-EMR2 antibody (AB75190)
  • WB

Unknown

Western blot - Anti-EMR2 antibody (AB75190)

All lanes:

Western blot - Anti-EMR2 antibody (ab75190) at 1/500 dilution

Lane 1:

HeLa cell extract at 10 µg

Lane 2:

HeLa cell extract at 10 µg with immunising peptide

Predicted band size: 90 kDa

Observed band size: 91 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ADGRE2. The exact immunogen used to generate this antibody is proprietary information.

Q9UHX3

style
left-column

보완 제품

Assay Kits

AB313688

Human EMR2 ELISA Kit

Sandwich ELISA - Human EMR2 ELISA Kit (AB313688)

  • 0
  • 0
Primary Antibodies

AB272329

APC Anti-PD-L1 antibody [10F.9G2]

Flow Cytometry - APC Anti-PD-L1 antibody [10F.9G2] (AB272329)

  • 0
  • 0
Primary Antibodies

AB108630

Anti-MGMT antibody [EPR4397]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MGMT antibody [EPR4397] (AB108630)

  • 0
  • 0
Multiplex Kits

AB169819

Human Obesity Antibody Array - Membrane (62 targets)

Multiplex Protein Detection - Human Obesity Antibody Array - Membrane (62 targets) (AB169819)

  • 0
  • 0
Proteins & Peptides

AB126670

Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human Junctional Adhesion Molecule 1/JAM-A protein (His tag N-Terminus) (AB126670)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab75190 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

EMR2 also known as epidermal growth factor-like module receptor 2 or CD312 is a member of the class B G protein-coupled receptor family. It is a large receptor with an approximate mass of 220 kDa. EMR2 is mainly expressed on leukocytes especially myeloid cells like monocytes and macrophages. EMR2 consists of an extensive extracellular domain that is involved in ligand binding influencing cell adhesion and signaling processes.
Biological function summary

EMR2 plays a role in the immune system by facilitating cell-cell interactions and guiding leukocyte trafficking. It forms part of a receptor complex that includes other G protein-coupled receptors. The receptor is essential in the regulation of inflammatory responses helping in the recognition and response to pathogens or tissue damage. EMR2's function contributes to the activation and migration of immune cells to sites of infection or injury.

Pathways

EMR2 interacts with intracellular signaling cascades such as the MAPK and PI3K pathways that manage cell proliferation survival and immune responses. Through these pathways EMR2 connects to proteins such as Akt and ERK facilitating downstream signaling mechanisms important for immune cell activation. The integration of EMR2 in these pathways positions it as an important player in cellular responses to external stimuli.

Aberrations in EMR2 function or expression relate to chronic inflammatory conditions and autoimmune disorders. Conditions such as rheumatoid arthritis and inflammatory bowel disease show altered EMR2 signaling indicating its role in the pathology of these diseases. In the context of these disorders other proteins like TNF-alpha and IL-6 often interact with EMR2 linking it to pro-inflammatory pathways and the exacerbation of disease symptoms.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed : 26841242).
See full target information ADGRE2

대체 명칭 보기

CD312, EMR2, ADGRE2, Adhesion G protein-coupled receptor E2, EGF-like module receptor 2, EGF-like module-containing mucin-like hormone receptor-like 2
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of neuroinflammation 22:173 PubMed40611130

2025

Factor-H-related protein 1 (FHR1), a promotor of para-inflammation in age-related macular degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Andjela Sekulic,Sarah M Herr,Kelly Mulfaul,Inga-Marie Pompös,Silvia Winkler,Carola Dietrich,Benedikt Obermayer,Robert F Mullins,Thomas Conrad,Peter F Zipfel,Florian Sennlaub,Christine Skerka,Olaf Strauß

Antioxidants (Basel, Switzerland) 14: PubMed40563263

2025

GG Modulates Mitochondrial Function and Antioxidant Responses in an Ethanol-Exposed In Vivo Model: Evidence of HIGD2A-Dependent OXPHOS Remodeling in the Liver.

Applications

Unspecified application

Species

Unspecified reactive species

Celia Salazar,Marlen Barreto,Alfredo Alfonso Adriasola-Carrasco,Francisca Carvajal,José Manuel Lerma-Cabrera,Lina María Ruiz
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com