AB197932

Anti-EPDR1 antibody - C-terminal

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(4 제품이 사용된 논문 )

Rabbit Polyclonal EPDR1 antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to EPDR1, fused to EPDR1.

대체 명칭 보기

MERP1, UCC1, EPDR1, Mammalian ependymin-related protein 1, MERP-1, Upregulated in colorectal cancer gene 1 protein

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPDR1 antibody - C-terminal (AB197932)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPDR1 antibody - C-terminal (AB197932)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling EPDR1 with ab197932 at 1/40 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Fusion protein corresponding to EPDR1, fused to EPDR1. The exact immunogen used to generate this antibody is proprietary information.

Q9UM22

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/40 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

EPDR1 also known as Ependymin-Related 1 is a protein involved in cellular adhesion and signaling. It has an approximate molecular mass of 55 kDa. EPDR1 is expressed in various tissues with significant levels found in the brain and also in some cancerous tissues. The protein plays a role in cellular interaction by mediating cell-cell and cell-matrix adhesion contributing to cellular cohesion and integrity.

Biological function summary

EPDR1 functions in processes of cell adhesion and immune response modulation. It may form complexes with other proteins that help regulate the structural organization of cells within tissue matrices. This modulation is essential for the repair and maintenance of tissue architecture actively influencing how cells respond to environmental changes.

Pathways

EPDR1 is significant in the ECM-receptor interaction pathway and plays a role in cell communication pathways. It interacts with other proteins like integrins which are important in mediating outside-in signaling processes. This interaction facilitates various downstream signaling events that are necessary for maintaining cell and tissue structure.

EPDR1 has been associated with cancer and neurodegenerative diseases. It may influence cancer progression through its impact on cell adhesion potentially affecting metastasis by altering cell motility and detachment. In neurological contexts the relationship with neurodegenerative diseases links to proteins like amyloid-beta where modulation by EPDR1 can affect disease progression by influencing cellular adhesion properties in neural tissues.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Binds anionic lipids and gangliosides at acidic pH.

See full target information EPDR1

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Aging cell 21:e13707 PubMed36087066

2022

The lysosomal proteome of senescent cells contributes to the senescence secretome.

Applications

Unspecified application

Species

Unspecified reactive species

Miguel Rovira,Rebecca Sereda,David Pladevall-Morera,Valentina Ramponi,Ines Marin,Mate Maus,Julio Madrigal-Matute,Antonio Díaz,Fernando García,Javier Muñoz,Ana María Cuervo,Manuel Serrano

JBMR plus 5:e10531 PubMed34532616

2021

CRISPR-Cas9-Mediated Genome Editing Confirms as an Effector Gene at the BMD GWAS-Implicated '' Locus.

Applications

Unspecified application

Species

Unspecified reactive species

James A Pippin,Alessandra Chesi,Yadav Wagley,Chun Su,Matthew C Pahl,Kenyaita M Hodge,Matthew E Johnson,Andrew D Wells,Kurt D Hankenson,Struan F A Grant

Scientific reports 10:3723 PubMed32111877

2020

EPDR1 up-regulation in human colorectal cancer is related to staging and favours cell proliferation and invasiveness.

Applications

Unspecified application

Species

Unspecified reactive species

F Gimeno-Valiente,Á L Riffo-Campos,G Ayala,N Tarazona,V Gambardella,F M Rodríguez,M Huerta,C Martínez-Ciarpaglini,J Montón-Bueno,S Roselló,D Roda,A Cervantes,L Franco,G López-Rodas,J Castillo

Nature communications 10:1260 PubMed30890710

2019

Genome-scale Capture C promoter interactions implicate effector genes at GWAS loci for bone mineral density.

Applications

Unspecified application

Species

Unspecified reactive species

Alessandra Chesi,Yadav Wagley,Matthew E Johnson,Elisabetta Manduchi,Chun Su,Sumei Lu,Michelle E Leonard,Kenyaita M Hodge,James A Pippin,Kurt D Hankenson,Andrew D Wells,Struan F A Grant

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-EPDR1 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-EPDR1 antibody - C-terminal (AB197932)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise