JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB89472

Anti-Ephrin A3 antibody [MM0262-7N12]

Be the first to review this product! 리뷰 제출

|

(3 제품이 사용된 논문 )

Mouse Monoclonal Ephrin A3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human EFNA3.
1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ephrin A3 antibody [MM0262-7N12] (AB89472)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ephrin A3 antibody [MM0262-7N12] (AB89472)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placental tissue section (4μm) labelling Ephrin with ab89472. Tissue was treated with 15μg/ml Protenase K for antigen retrieval and fixed with 4% PFA. A HRP-conjugated anti-mouse IgG was used as the secondary antibody (30 minutes at room temperature) followed by DAB color development.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0262-7N12

Isotype

IgG2

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human EFNA3. The exact immunogen used to generate this antibody is proprietary information.

P52797

style
left-column

대체품

Primary Antibodies

AB64814

Anti-Ephrin A3 antibody

Western blot - Anti-Ephrin A3 antibody (AB64814)

  • 4
  • 4

보완 제품

Primary Antibodies

AB187904

Anti-RHCG antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-RHCG antibody (AB187904)

  • 0
  • 0
Primary Antibodies

AB39155

Anti-ADAM12 antibody - Aminoterminal end

Western blot - Anti-ADAM12 antibody - Aminoterminal end (AB39155)

  • 4
  • 3
Primary Antibodies

AB307601

Anti-xCT antibody [EPR27115-64]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-xCT antibody [EPR27115-64] (AB307601)

  • 5
  • 1
Primary Antibodies

AB199178

Anti-Connexin 30.3 / GJB4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Connexin 30.3 / GJB4 antibody (AB199178)

  • 3
  • 1
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
The IgG fraction of culture supernatant was purified and 0.2 µm filtered.
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Ephrin A3 also known as Ephrin-A3 or EFNA3 is a member of the ephrin family that interacts with Eph receptors which are a group of tyrosine kinase receptors. Ephrin A3 has a mass of approximately 24 kDa. It is expressed in various tissues including the brain where it plays a significant role in neural development. The expression pattern of Ephrin A3 suggests its involvement in a wide range of physiological processes.
Biological function summary

Ephrin A3 acts as an important regulator in cell communication and spatial organization within the brain's neuronal network. It forms a complex with Eph receptors on adjacent cells leading to bidirectional signaling necessary for processes like axon guidance and synaptic plasticity. Ephrin A3's ability to guide axons is important for neural pathfinding during development. It also participates in the clustering of neurons required for the formation of precise neural circuits.

Pathways

Ephrin A3 is a significant player in the Eph/ephrin signaling pathway which influences the dynamics of cell adhesion shape and movement. It is closely related to EphA3 and EphA4 receptors through these pathways. The signaling influences the cytoskeleton affecting cell migration and tissue boundary formation. Additionally Ephrin A3 interacts within the Rho family of GTPase signaling pathways that regulate cytoskeletal rearrangements impacting cellular morphology and motility.

Ephrin A3 is implicated in conditions like cancer and neurological disorders. Aberrant expression or signaling of Ephrin A3 contributes to tumor progression and metastasis potentially through its role in modifying cell adhesion and migration. Through its involvement in the neural network it may also relate to neurodegenerative diseases. The interaction with proteins like EphA2 in cancer highlights its potential as a therapeutic target. Understanding these interactions opens pathways for strategies to modulate its function in disease contexts.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
See full target information EFNA3

대체 명칭 보기

EFL2, EPLG3, LERK3, EFNA3, Ephrin-A3, EFL-2, EHK1 ligand, EPH-related receptor tyrosine kinase ligand 3, EHK1-L, LERK-3
style
left-column

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

American journal of translational research 14:8903-8917 PubMed36628218

2022

Long non-coding RNA HOTTIP induces inflammation in asthma by promoting EFNA3 transcription by CCCTC-binding factor.

Applications

Unspecified application

Species

Unspecified reactive species

Qiong Wu,Jinming Liu,Jie Deng,Yuanjing Chen

Cancer cell international 21:535 PubMed34645436

2021

EFNA3 as a predictor of clinical prognosis and immune checkpoint therapy efficacy in patients with lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Mingming Deng,Run Tong,Zhe Zhang,Tao Wang,Chaonan Liang,Xiaoming Zhou,Gang Hou

Frontiers in immunology 10:2253 PubMed31616427

2019

Distinct Autoimmune Anti-α-Synuclein Antibody Patterns in Multiple System Atrophy and Parkinson's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Jonas Folke,Rasmus Rydbirk,Annemette Løkkegaard,Lisette Salvesen,Anne-Mette Hejl,Charlotte Starhof,Sára Bech,Kristian Winge,Søren Christensen,Lars Østergaard Pedersen,Susana Aznar,Bente Pakkenberg,Tomasz Brudek
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com