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AB219996

Anti-ESCO2 antibody

5

(1 리뷰)

|

(1 출판물)

Rabbit Polyclonal ESCO2 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ESCO2 aa 300-400.

대체 명칭 보기

N-acetyltransferase ESCO2, Establishment factor-like protein 2, Establishment of cohesion 1 homolog 2, EFO2, EFO2p, hEFO2, ECO1 homolog 2, ESCO2

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-ESCO2 antibody (AB219996)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ESCO2 antibody (AB219996)

Immunofluorescent analysis of PFA-fixed, triton X-100 permeabilized U-2 OS cells labeling ESCO2 with ab219996 at 4 μg/ml (green).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human ESCO2 aa 300-400. The exact immunogen used to generate this antibody is proprietary information.

Q56NI9

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보완 제품

Primary Antibodies

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Primary Antibodies

AB15093

Anti-SCP3 antibody

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Primary Antibodies

AB92536

Anti-MMP2 antibody [EPR1184]

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Primary Antibodies

AB96133

Anti-Cyclin T2/CCNT2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Cyclin T2/CCNT2 antibody (AB96133)

  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

ESCO2 also known as Establishment of Sister Chromatid Cohesion N-Acetyltransferase 2 is a protein with a mass of about 68 kDa. It is expressed widely across various human tissues with notable presence in proliferating cells. ESCO2 has a mechanistic role in the establishment of sister chromatid cohesion during the S phase of the cell cycle. It works by acetylating the cohesin subunit SMC3 which is essential for proper chromosome segregation during mitosis and meiosis.
Biological function summary

ESCO2 functions as a part of the chromosomal cohesion complex which is necessary for maintaining genome stability. The cohesion complex ensures that sister chromatids remain paired from DNA replication in S phase until anaphase. This complex requires synchronized action of cohesin proteins including STAG2 and RAD21 which work together with ESCO2 to ensure the fidelity of chromosomal transmission. By facilitating proper cohesion ESCO2 prevents aneuploidy which is often incompatible with cell viability.

Pathways

The protein ESCO2 interacts with the cell cycle regulatory pathways and chromosomal dynamics. Within these pathways ESCO2 cooperates with proteins like CDK1 and PLK1. These interactions help drive critical transitions between various phases of the cell cycle primarily assuring that chromosomes align correctly and segregate during mitosis. As ESCO2 modifies SMC3 via acetylation this modification is important for the action of the cohesin complex allowing it to perform its functions within the cell cycle control mechanisms.

ESCO2 has significant implications in Roberts Syndrome and certain cancers. Roberts Syndrome a developmental disorder results from mutations in the ESCO2 gene leading to defective cohesion. This defect impacts cell proliferation and differentiation contributing to the syndrome's phenotypic features. In cancer biology abnormal ESCO2 expression or function can result in genomic instability promoting oncogenesis. The interplay of ESCO2 with cohesin proteins like SMC3 and STAG2 highlights its critical role in maintaining chromosomal integrity essential for preventing disease.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed : 15821733, PubMed : 15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed : 21111234).
See full target information ESCO2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of cell communication and signaling 19:e70037 PubMed40717692

2025

Cancer-associated fibroblasts-secreted lactate promotes RNA polymerase III subunit G-mediated epithelial-mesenchymal transition in non-small cell lung cancer by increasing m6A modification of zinc finger protein 384.

Applications

Unspecified application

Species

Unspecified reactive species

Ping Li,Xing Yang,Hao Tang,Zhiping Zhou,Bin Liu
제품이 사용된 논문 모두 보기
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Product promise

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