AB224591

Anti-ESM1 antibody

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(10 제품이 사용된 논문 )

Rabbit Polyclonal ESM1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Endothelial cell-specific molecule 1 aa 1-200.

대체 명칭 보기

Endothelial cell-specific molecule 1, ESM-1, ESM1

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESM1 antibody (AB224591)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESM1 antibody (AB224591)

Paraffin-embedded human lung tissue tissue stained for ESM1 using ab224591 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Endothelial cell-specific molecule 1 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9NQ30

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Endothelial cell-specific molecule 1 (ESM1) also known as endocan is a proteoglycan with a mass of approximately 50 kDa. It is primarily expressed in endothelial cells of blood vessels particularly in the lungs and the kidneys. ESM1 consists of a core protein covalently attached to dermatan sulfate chains. Its expression often increases under inflammatory conditions which highlights its role in vascular biology.

Biological function summary

ESM1 acts in the regulation of cell adhesion and migration processes. It interacts with leukocytes and participates in modulating inflammatory responses. ESM1 does not form part of a multi-protein complex but its activity can influence the behavior of other cell surface molecules and receptors. This function positions ESM1 as a critical player in the dynamics of vascular endothelium.

Pathways

ESM1 modulates inflammation and angiogenesis by participating in pathways involving vascular endothelial growth factor (VEGF). It interacts with proteins such as VEGF receptor-2 impacting endothelial permeability and new blood vessel formation. These interactions situate ESM1 within the signaling networks that regulate endothelial function and vascular homeostasis.

Research associates ESM1 with conditions such as sepsis and cancer. High levels of this molecule correlate with poor prognosis in these diseases linking it functionally to VEGF and other factors involved in abnormal endothelial cell activity. Understanding ESM1's role provides insights into mechanisms of disease progression and potential therapeutic targets.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Involved in angiogenesis; promotes angiogenic sprouting. May have potent implications in lung endothelial cell-leukocyte interactions.

See full target information Endothelial cell-specific molecule 1

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제품이 사용된 논문 (10)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Diagnostics (Basel, Switzerland) 15: PubMed40506951

2025

The Role of Endocan Expression in the Diagnosis and Grading of Precancerous Gastric Lesions.

Applications

Unspecified application

Species

Unspecified reactive species

Mehmet Kok,Suleyman Dolu,Mehmet Emin Arayici,Gokhan Koker,Kadir Balaban,Ayhan Hilmi Cekin

Scientific reports 15:13355 PubMed40247075

2025

Upper airway microcirculation remodeling in obstructive sleep apnea is not driven by endothelial activation.

Applications

Unspecified application

Species

Unspecified reactive species

Kristine Fahl,Thais Mauad,Jôse M de Brito,Natalia S X Costa,Danielle A S Dantas,Heraldo Possolo de Souza,Roney O Sampaio,Luiz U Sennes,Michel B Cahali

Scientific reports 15:4902 PubMed39929852

2025

ESM1 promote proliferation, invasion and angiogenesis via Akt/mTOR and Ras pathway in kidney renal clear cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjun Luo,Ting Yi,Yong Wang,Wei Song,Zhiyong Gao,Jiansong Wang,Yukun Li

Cellular and molecular biology (Noisy-le-Grand, France) 69:160-167 PubMed37605575

2023

Identification of ESM1 as a Potential Biomarker Involving Drug Sensitivity and the Tumor Immune Microenvironment that Promotes Proliferation of Melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Miaomiao Wang,Hongfen Ge,Shuya Liang,Guanzhi Chen

International journal of biological sciences 19:258-280 PubMed36594088

2023

Validation of ESM1 Related to Ovarian Cancer and the Biological Function and Prognostic Significance.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Kun Li,Tian Zeng,Yang Guan,Jue Liu,Nian-Chun Liao,Meng-Jie Wang,Ke-Xin Chen,Xian-Yu Luo,Chang-Ye Chen,Fei-Fei Quan,Juan Wang,Qun-Feng Zhang,Juan Zou

Open medicine (Warsaw, Poland) 17:1376-1389 PubMed36117773

2022

Endothelial cell-specific molecule 1 (ESM1) promoted by transcription factor SPI1 acts as an oncogene to modulate the malignant phenotype of endometrial cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yu He,Lu Lin,Yurong Ou,Xiaowen Hu,Chi Xu,Caizhi Wang

Thrombosis and haemostasis 122:1513-1523 PubMed35170008

2022

Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture.

Applications

Unspecified application

Species

Unspecified reactive species

Susanne Metschl,Lukas Bruder,Valentina Paloschi,Katharina Jakob,Benedikt Reutersberg,Christian Reeps,Lars Maegdefessel,Michael Gee,Hans-Henning Eckstein,Jaroslav Pelisek

Molecular therapy. Nucleic acids 18:787-800 PubMed31734559

2019

Exosomal MicroRNA-9-3p Secreted from BMSCs Downregulates ESM1 to Suppress the Development of Bladder Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hongzhou Cai,Xuejian Yang,Yang Gao,Zicheng Xu,Bin Yu,Ting Xu,Xiao Li,Weizhang Xu,Xinwei Wang,Lixin Hua

iScience 19:872-882 PubMed31513972

2019

ALDH1A3 Regulations of Matricellular Proteins Promote Vascular Smooth Muscle Cell Proliferation.

Applications

Unspecified application

Species

Unspecified reactive species

Xiujie Xie,Go Urabe,Lynn Marcho,Matthew Stratton,Lian-Wang Guo,Craig K Kent

Scientific reports 9:1854 PubMed30755622

2019

Endocan as a marker of microvascular inflammation in kidney transplant recipients.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Ho Lee,Se-Yun Kim,Haena Moon,Jung-Woo Seo,Dong-Jin Kim,Seon Hwa Park,Yang-Gyun Kim,Ju-Young Moon,Jin Sug Kim,Kyung-Hwan Jeong,Sung-Jig Lim,Chan-Duck Kim,Jae Berm Park,Byung Ha Chung,Yeong Hoon Kim,Jaeseok Yang,Hyung-In Yang,Kyoung Soo Kim,Sang-Ho Lee

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ESM1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ESM1 antibody (AB224591)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (10)

Product promise