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AB241064

Anti-Estrone antibody [EPPTX-R7-94-2]

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Rabbit Recombinant Monoclonal Estrone antibody. Suitable for cELISA and reacts with Chemical samples. Cited in 1 publication.

대체 명칭 보기

Oestrone

2 이미지
Competitive ELISA - Anti-Estrone antibody [EPPTX-R7-94-2] (AB241064)
  • cELISA

Unknown

Competitive ELISA - Anti-Estrone antibody [EPPTX-R7-94-2] (AB241064)

Goat anti-rabbit IgG was coated onto 96-wells. Serial dilution of Estrone-6 (0, 15, 30, 100, 250, 500, 1000, 2000pg/mL) was added (25μL). This was followed by adding of 50μL of HRP-conjugated Estrone and 2.0-2.5ng/mL ab241064 (50μL) into each well. Plates were incubated for 2 hours at room temperature by shaking. After washing, 125μL of Tetramethylbenzidine (TMB) substrate was added and incubated for 30 minutes without shaking for color development. Then 125 μL of stopping solution (acid solution) was dispensed and OD was read at 450nm on a microplate reader within 5 minutes.

This data was kindly provided by Pantex Division of Bio-Analysis, Inc.

Competitive ELISA - Anti-Estrone antibody [EPPTX-R7-94-2] (AB241064)
  • cELISA

Unknown

Competitive ELISA - Anti-Estrone antibody [EPPTX-R7-94-2] (AB241064)

ELISA - Anti-Estrone antibody [EPPTX-R7-94-2] (ab241064) at 2.0 ng/ml.

ab241064 is specific to Estrone-6 and the percent cross reactivity with other compounds is demonstrated in the table.

This data was kindly provided by Pantex Division of Bio-Analysis, Inc.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • Carrier free

    Anti-Estrone antibody [EPPTX-R7-94-2] - BSA and Azide free

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPPTX-R7-94-2

Isotype

IgG

Carrier free

No

Applications

cELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Primary Antibodies

AB222404

Anti-Progesterone antibody [EPPTX-R1] - Low endotoxin, Azide free

RabMAb|Recombinant

Competitive ELISA - Anti-Progesterone antibody [EPPTX-R1] - Low endotoxin, Azide free (AB222404)

  • 0
  • 0
Primary Antibodies

AB240648

Anti-SMARCA2 / BRM antibody [EPR23103-44]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SMARCA2 / BRM antibody [EPR23103-44] (AB240648)

  • 0
  • 0
Primary Antibodies

AB167453

Anti-mCherry antibody

Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-mCherry antibody (AB167453)

  • 5
  • 17
Primary Antibodies

AB213511

Anti-mCherry antibody [EPR20579]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Flow Cytometry - Anti-mCherry antibody [EPR20579] (AB213511)

  • 4
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "cELISA" : {"fullname" : "Competitive ELISA", "shortname":"cELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "cELISA-species-checked": "testedAndGuaranteed", "cELISA-species-dilution-info": "0.002-0.0025 µg/mL", "cELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Estrone also known as E1 acts as a steroidal estrogen hormone with a molecular weight of approximately 270.4 g/mol. It is commonly expressed in the ovaries adipose tissue and liver. Estrone serves as one of the three major estrogens found in humans alongside estradiol and estriol. As a part of estrogen family it engages in binding to estrogen receptors influencing gene expression and physiological responses in target tissues.
Biological function summary

Estrogen hormones like estrone play significant roles in feminine reproductive health and secondary sexual characteristics. Estrone maintains a balance through conversion to and from other estrogens within the body. It does not function as a complex but influences biological processes such as cell proliferation and tissue growth particularly in reproductive organs. By interacting with cellular mechanisms estrone significantly impacts various physiological responses.

Pathways

Steroid hormones such as estrone integrate into metabolic and reproductive pathways. In the biosynthesis of steroids estrone converts from androstenedione or estradiol through enzymatic actions. The estrogen signaling pathway involves estrone and proteins such as estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). ERα and ERβ modulate transcriptional activities in various estrogen-responsive genes.

Hormonal imbalances involving estrone can contribute to conditions such as breast cancer and osteoporosis. In breast cancer overexpression of estrone can lead to proliferation of cancerous cells through its interaction with ERα and ERβ proteins. In osteoporosis altered levels of estrone in conjunction with decreased estrogen levels generally result in reduced bone density and mass leading to higher fracture risks. Estrone’s relationship with these disorders highlights its impact on human health.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information Estrone
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 12: PubMed37874635

2023

Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson's disease-linked LRRK2 kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Herschel S Dhekne,Francesca Tonelli,Wondwossen M Yeshaw,Claire Y Chiang,Charles Limouse,Ebsy Jaimon,Elena Purlyte,Dario R Alessi,Suzanne R Pfeffer
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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