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AB244446

Anti-EXOC2 antibody

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Rabbit Polyclonal EXOC2 antibody. Suitable for ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human EXOC2 aa 50-200.

대체 명칭 보기

SEC5, SEC5L1, EXOC2, Exocyst complex component 2, Exocyst complex component Sec5

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-EXOC2 antibody (AB244446)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-EXOC2 antibody (AB244446)

PFA-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for EXOC2 (green) using ab244446 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human EXOC2 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q96KP1

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대체품

Primary Antibodies

AB140620

Anti-EXOC2 antibody [EPR9420]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-EXOC2 antibody [EPR9420] (AB140620)

  • 5
  • 1

보완 제품

Primary Antibodies

AB224484

Anti-Sec8 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sec8 antibody (AB224484)

  • 0
  • 0
Primary Antibodies

AB95981

Anti-EXOC7 antibody

Immunocytochemistry/ Immunofluorescence - Anti-EXOC7 antibody (AB95981)

  • 0
  • 0
Primary Antibodies

AB220784

Anti-Pericentrin antibody [EPR21987] - Centrosome Marker

RabMAb|Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Pericentrin antibody [EPR21987] - Centrosome Marker (AB220784)

  • 4
  • 2
Primary Antibodies

AB4447

Anti-Ninein/NIN antibody - Centrosome Marker

Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-Ninein/NIN antibody - Centrosome Marker (AB4447)

  • 5
  • 3
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The exocyst complex component 2 also known as EXOC2 or SEC5 is an important protein involved in vesicle trafficking. EXOC2 has an estimated mass of around 105 kDa. It is widely expressed in various tissues highlighting its broad significance in cellular processes. Its primary role is to participate in the tethering of secretory vesicles to specific sites on the plasma membrane aiding in processes like cell migration and growth.
Biological function summary

EXOC2 acts as a fundamental part of the exocyst complex which comprises eight proteins. This complex orchestrates vesicle targeting and tethering during exocytosis a process essential for maintaining cell surface area and membrane protein composition. Unlike other vesicle trafficking complexes the exocyst shows significant specificity for certain vesicles and localization contributing to the precision of membrane-associated functions.

Pathways

EXOC2 joins key pathways like the insulin signaling pathway and the regulation of actin cytoskeleton. In the insulin signaling pathway EXOC2 integrates with components such as the protein Rab11 to mediate glucose transporter vesicle trafficking impacting glucose uptake. In the regulation of the actin cytoskeleton it interacts with actin-related proteins to influence cell shape and motility.

Connection with EXOC2 influences conditions such as cancer and diabetes. Abnormal EXOC2 expression links to various cancers often through disruptions in cellular trafficking and signal transduction. The interplay with diabetes arises partly through its role in insulin-mediated processes with proteins like Rab11 that affect glucose homeostasis. These associations highlight the potential for EXOC2 as a therapeutic target in these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
See full target information EXOC2
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Product promise

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