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AB61370

Anti-Factor VIII antibody

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(3 제품이 사용된 논문 )

Sheep Polyclonal Factor VIII antibody. Suitable for ELISA, FuncS (Neut/Block) and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human F8.

주요 정보

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

FuncS (Neut/Block), ELISA

applications

Immunogen

Recombinant Full Length Protein corresponding to Human F8.

P00451

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대체품

Primary Antibodies

AB78852

Anti-Factor VIII antibody [GMA-012]

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor VIII antibody [GMA-012] (AB78852)

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  • 0
Primary Antibodies

AB171825

Anti-Factor VIII antibody

  • 0
  • 0
Primary Antibodies

AB203590

Anti-Factor VIII antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor VIII antibody (AB203590)

  • 0
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Primary Antibodies

AB236284

Anti-Factor VIII antibody

Immunocytochemistry/ Immunofluorescence - Anti-Factor VIII antibody (AB236284)

  • 0
  • 0

보완 제품

Assay Kits

AB108830

Factor VII Activity Assay Kit (Human, Colorimetric)

Functional Studies - Factor VII Activity Assay Kit (Human, Colorimetric) (AB108830)

  • 0
  • 0
Assay Kits

AB279889

Phospho-PDK1 (S241) and Total PDK1 ELISA Kit

Sandwich ELISA - Phospho-PDK1 (S241) and Total PDK1 ELISA Kit (AB279889)

  • 0
  • 0
Proteins & Peptides

AB158403

Recombinant Human Factor VIII protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human Factor VIII protein (GST tag N-Terminus) (AB158403)

  • 0
  • 0
Primary Antibodies

AB11713

Anti-Von Willebrand Factor antibody

  • 4
  • 14
Primary Antibodies

AB281583

Anti-CD31 antibody [RM1006]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody [RM1006] (AB281583)

  • 5
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p>Binds FVIII/vWF complex in plasma.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Ion exchange chromatography
Purification 관련 사항
Salt fractionation followed by ion exchange chromatography.
보관 버퍼
Constituents: 50% Glycerol (glycerin, glycerine), 50% Water
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Factor VIII also known as anti-hemophilic factor is a glycoprotein with a molecular mass of approximately 250 kDa. This protein circulates in the plasma mainly in the liver where hepatocytes produce it. Factor VIII remains inactive while circulating in the blood and exists within the factor VIII/von Willebrand factor complex. Upon activation it plays a significant role in the blood coagulation process.
Biological function summary

Factor VIII greatly contributes to hemostasis by serving as a cofactor for factor IXa forming the intrinsic tenase complex. This activation results in the conversion of factor X to factor Xa which is important for the common pathway of the coagulation cascade. By participating in the clotting process factor VIII ensures proper wound healing and prevention of blood loss.

Pathways

Factor VIII activity is pivotal within the coagulation cascade particularly the intrinsic and common pathways. Activation of the intrinsic pathway begins through interactions with factor IXa leading to efficient activation of factor X. This process closely relates factor VIII to proteins like factor IX and factor X ensuring proper clot formation and stabilization. Factor VIII products and assays are available to study and characterize its critical role in these pathways.

Factor VIII is closely associated with hemophilia A a genetic bleeding disorder resulting from deficiency or dysfunction of this protein. Patients with hemophilia A exhibit prolonged bleeding times due to impaired coagulation. The disorder links directly to von Willebrand factor as it protects factor VIII from degradation in circulation stabilizing its presence in the blood. Anti-factor VIII antibodies are important tools for diagnosing and studying factor VIII-related disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
See full target information F8

대체 명칭 보기

F8C, F8, Coagulation factor VIII, Antihemophilic factor, Procoagulant component, AHF
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Drug delivery 32:2449376 PubMed39789884

2025

In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Joaquín Yanes-Díaz,Raquel Palao-Suay,Francisca Inmaculada Camacho-Castañeda,Juan Riestra-Ayora,María Rosa Aguilar,Ricardo Sanz-Fernández,Carolina Sánchez-Rodríguez

Journal of thrombosis and haemostasis : JTH 18:306-317 PubMed31562694

2019

A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A.

Applications

Unspecified application

Species

Unspecified reactive species

Kathryn G Link,Michael T Stobb,Matthew G Sorrells,Maria Bortot,Katherine Ruegg,Marilyn J Manco-Johnson,Jorge A Di Paola,Suzanne S Sindi,Aaron L Fogelson,Karin Leiderman,Keith B Neeves

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 26:755-61 PubMed26192111

2015

Comparison of human coagulation factor VIII expression directed by cytomegalovirus and mammary gland-specific promoters in HC11 cells and transgenic mice.

Applications

ELISA

Species

Unspecified reactive species

Qing Wang,Siguo Hao,Liyuan Ma,Wenhao Zhang,Jiangbo Wan,Xiaohui Deng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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