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AB89334

Anti-Factor X + Xa antibody [MM0192-10A10]

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Mouse Monoclonal Factor X antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human F10.
1 이미지
Western blot - Anti-Factor X + Xa antibody [MM0192-10A10] (AB89334)
  • WB

Supplier Data

Western blot - Anti-Factor X + Xa antibody [MM0192-10A10] (AB89334)

All lanes:

Western blot - Anti-Factor X + Xa antibody [MM0192-10A10] (ab89334) at 1/500 dilution

All lanes:

Human placenta tissue lysate

Observed band size: 59 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

MM0192-10A10

Isotype

IgG1

Light chain 타입

kappa

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human F10.

P00742

Specificity

<p>ab89334 detects Factor X and Xa.</p>

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보완 제품

Assay Kits

AB108833

Factor X Human Chromogenic Activity Assay Kit

Functional Studies - Factor X Human Chromogenic Activity Assay Kit (AB108833)

  • 0
  • 0
Assay Kits

AB289650

Human Factor X ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Factor X ELISA Kit (AB289650)

  • 0
  • 0
Primary Antibodies

AB228968

Anti-Tissue Factor antibody [EPR22548-232]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-Tissue Factor antibody [EPR22548-232] (AB228968)

  • 4
  • 1
Primary Antibodies

AB97614

Anti-Factor VII antibody

Western blot - Anti-Factor VII antibody (AB97614)

  • 0
  • 1
Assay Kits

AB220653

Human Tissue Factor ELISA Kit

Recombinant|SimpleStep

ELISA - Human Tissue Factor ELISA Kit (AB220653)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography and lyophilized from a 0.2 µm filtered solution.
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Factor X also known as Stuart-Prower factor and its active form Factor Xa play key roles in the blood coagulation cascade. Factor X is a serine protease with a molecular mass of approximately 59 kDa. It is synthesized in the liver and circulates in the plasma as an inactive precursor. Upon activation to Factor Xa it catalyzes the conversion of prothrombin to thrombin an important step in the clotting process that leads to the formation of a blood clot.
Biological function summary

Factor X and its active form Xa play a central role in coagulation. They are part of a complex known as the prothrombinase complex which includes Factor V calcium ions and phospholipids. This complex rapidly enhances the conversion of prothrombin to thrombin which then facilitates the conversion of fibrinogen to fibrin forming a stable fibrin clot. Factor Xa is tightly regulated by inhibitors such as antithrombin to ensure balanced coagulation.

Pathways

Factor X and Xa are integral to the intrinsic and extrinsic pathways of coagulation which converge at the activation of Factor X. In the intrinsic pathway the activation involves interactions with other factors such as Factor IX and VIII. Meanwhile in the extrinsic pathway tissue factor (Factor III) and Factor VIIa initiate the cascade leading to Factor X activation. These pathways illustrate the interconnectedness and regulatory mechanisms involved in hemostasis.

Factor X and Xa have significant implications. Deficiencies or dysfunctions in Factor X can lead to a rare bleeding disorder known as Factor X deficiency characterized by symptoms such as nosebleeds and gastrointestinal bleeding. Conversely excessive activity or inadequate regulation of these factors is linked to thrombotic conditions such as deep vein thrombosis. In such cases proteins like antithrombin and tissue factor pathway inhibitor become critical in managing the increased coagulation risk.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting (PubMed : 22409427, PubMed : 39880037). Factor Xa activates pro-inflammatory signaling pathways in a protease-activated receptor (PAR)-dependent manner (PubMed : 24041930, PubMed : 30568593, PubMed : 34831181, PubMed : 18202198). Up-regulates expression of protease-activated receptors (PARs) F2R, F2RL1 and F2RL2 in dermal microvascular endothelial cells (PubMed : 35738824). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, in cardiac fibroblasts and umbilical vein endothelial cells in PAR-1/F2R-dependent manner (PubMed : 30568593, PubMed : 34831181). Triggers the production of pro-inflammatory cytokines, such as MCP-1/CCL2, IL6, TNF/TNF, IL-1beta/IL1B, IL8/CXCL8 and IL18, in endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824, PubMed : 9780208). Induces expression of adhesion molecules, such as ICAM1, VCAM1 and SELE, in endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824, PubMed : 9780208). Increases expression of phosphorylated ERK1/2 in dermal microvascular endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824). Triggers activation of the transcription factor NF-kappa-B in dermal microvascular endothelial cells and atrial tissues (PubMed : 24041930, PubMed : 35738824). Activates pro-inflammatory and pro-fibrotic responses in dermal fibroblasts and enhances wound healing probably via PAR-2/F2RL1-dependent mechanism (PubMed : 18202198). Activates barrier protective signaling responses in endothelial cells in PAR-2/F2RL1-dependent manner; the activity depends on the cleavage of PAR-2/F2RL1 by factor Xa (PubMed : 22409427). Up-regulates expression of plasminogen activator inhibitor 1 (SERPINE1) in atrial tissues (PubMed : 24041930).
See full target information F10

대체 명칭 보기

Coagulation factor X, Stuart factor, Stuart-Prower factor, F10
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 14: PubMed36497399

2022

Ciliary Neurotrophic Factor Modulates Multiple Downstream Signaling Pathways in Prostate Cancer Inhibiting Cell Invasiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Giovanni Tossetta,Sonia Fantone,Rosaria Gesuita,Gaia Goteri,Martina Senzacqua,Fabio Marcheggiani,Luca Tiano,Daniela Marzioni,Roberta Mazzucchelli
제품이 사용된 논문 모두 보기
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Product promise

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