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AB317120

Anti-FAH antibody [HL1970]

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Rabbit Recombinant Monoclonal Fumarylacetoacetate hydrolase/FAA antibody. Suitable for WB, IHC-P and reacts with Transfected cell lysate, Human, Mouse, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human FAH.

대체 명칭 보기

Fumarylacetoacetase, FAA, Beta-diketonase, Fumarylacetoacetate hydrolase, FAH

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAH antibody [HL1970] (AB317120)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAH antibody [HL1970] (AB317120)

ab317120 detects FAH protein at cytoplasm by immunohistochemical analysis.
Sample : Paraffin-embedded rat liver.
FAH stained by ab317120 diluted at 1 : 100.
Antigen Retrieval : Citrate buffer pH 6.0 15 min.

Western blot - Anti-FAH antibody [HL1970] (AB317120)
  • WB

Supplier Data

Western blot - Anti-FAH antibody [HL1970] (AB317120)

Rat tissue extract (50 ug) was separated by 10% SDS-PAGE and the membrane was blotted with ab317120 diluted at 1 : 1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.

All lanes:

Western blot - Anti-FAH antibody [HL1970] (ab317120) at 1/1000 dilution

All lanes:

Rat liver tissue extract at 50 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

HL1970

Isotype

IgG

Carrier free

No

Reacts with

Human, Mouse, Rat

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FAH.

P16930

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보완 제품

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Primary Antibodies

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>" }, "Transfected cell lysate": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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제품 세부 정보

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Fumarylacetoacetate hydrolase (FAH) sometimes known as FAA hydrolase is an enzyme involved in the last step of tyrosine degradation. It catalyzes the hydrolysis of fumarylacetoacetate into fumarate and acetoacetate facilitating the breakdown of amino acids. This enzyme typically has a molecular mass of around 46 kDa. FAH is mostly expressed in the liver and kidneys reflecting its role in detoxifying metabolic byproducts in these organs.
Biological function summary

FAH plays a critical role in the catabolism of the amino acid tyrosine. It functions as a monomer rather than part of a larger protein complex. The enzyme's activity ensures the conversion of potentially toxic intermediates into less harmful components that the body can either utilize or excrete. This conversion is essential for maintaining metabolic equilibrium and preventing the accumulation of toxic metabolites which can damage cells.

Pathways

FAH is integral to the tyrosine degradation pathway. The breakdown process involves several enzymes with FAH being the final step converting fumarylacetoacetate. Enzymes like homogentisate 12-dioxygenase which acts earlier in the pathway are related to FAH within this context. This pathway is important for energy production and the synthesis of important biomolecules making each step's function interconnected with cellular health and metabolism.

Defects in FAH activity lead to hereditary tyrosinemia type I a metabolic disorder characterized by the accumulation of toxic intermediates due to disrupted tyrosine degradation. This disorder results in severe liver and kidney damage if not managed appropriately. Other proteins such as tyrosine aminotransferase can also be affected by analogous disruptions in the same metabolic pathway contributing to metabolic diseases when their function becomes impaired through the pathway's imbalances.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information FAH
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Product promise

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