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AB222206

Anti-FAN1 antibody

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Rabbit Polyclonal FAN1 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FAN1 aa 900 to C-terminus.

대체 명칭 보기

KIAA1018, MTMR15, FAN1, Fanconi-associated nuclease 1, FANCD2/FANCI-associated nuclease 1, Myotubularin-related protein 15, hFAN1

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-FAN1 antibody (AB222206)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAN1 antibody (AB222206)

PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for FAN1 (green) using ab222206 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human FAN1 aa 900 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9Y2M0

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대체품

Primary Antibodies

AB68572

Anti-FAN1 antibody

  • 4
  • 1
Primary Antibodies

AB95171

Anti-FAN1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAN1 antibody (AB95171)

  • 0
  • 0

보완 제품

Biochemicals

AB120129

Y-27632 dihydrochloride, Rho kinase inhibitor

Functional Studies - Y-27632 dihydrochloride, Rho kinase inhibitor (AB120129)

  • 5
  • 2
Primary Antibodies

AB241545

Anti-Werner's syndrome helicase WRN antibody [195C]

BOND RX™ Validated|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Werner's syndrome helicase WRN antibody [195C] (AB241545)

  • 0
  • 0
Primary Antibodies

AB188235

Anti-RAD18 antibody

Immunocytochemistry/ Immunofluorescence - Anti-RAD18 antibody (AB188235)

  • 0
  • 0
Primary Antibodies

AB108928

Anti-FANCD2 antibody [EPR2302]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-FANCD2 antibody [EPR2302] (AB108928)

  • 5
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FAN1 also known as Fanconi-associated nuclease 1 is a protein implicated in DNA repair processes. The protein has a molecular mass of approximately 101 kDa. FAN1 can be found in various tissues with enriched expression in testis thymus and liver. It operates as a nuclease engaging in processes to remove DNA crosslinks maintaining the integrity of genetic material.
Biological function summary

FAN1 plays a significant role in the repair of interstrand cross-links within DNA. FAN1 acts as part of a complex that detects and processes these cross-links aiding in cell survival by preventing genome instability. It connects with the Fanconi anemia pathway proteins which include FANCD2 and FANCI to promote the repair process. The function of FAN1 is critical in preserving cellular health under conditions that could potentially damage DNA.

Pathways

FAN1 exists prominently in the DNA damage response and the Fanconi anemia pathway. It interacts closely with proteins such as MLH1 tying into a broader network of repair mechanisms. These pathways are essential for cellular resistance to various stressors that threaten genomic stability. FAN1's precise involvement ensures cells can effectively manage DNA damage contributing to proper functioning of genetic repair networks.

FAN1 displays connections with two significant conditions: Fanconi anemia and colorectal cancer. Mutations or deficiencies in FAN1 can lead to increased susceptibility to genomic instability disorders like Fanconi anemia. The protein also associates with proteins like PMS2 and MLH1 which when mutated contribute to colorectal cancer. Understanding FAN1's role offers insight into therapeutic targets and genetic predispositions related to these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Nuclease required for the repair of DNA interstrand cross-links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (PubMed : 20603015, PubMed : 20603016, PubMed : 20603073, PubMed : 20671156, PubMed : 24981866, PubMed : 25430771). Not involved in DNA double-strand breaks resection (PubMed : 20603015, PubMed : 20603016). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Probably keeps excising with 3'-flap annealing until it reaches and unhooks the ICL (PubMed : 25430771). Acts at sites that have a 5'-terminal phosphate anchor at a nick or a 1- or 2-nucleotide flap and is augmented by a 3' flap (PubMed : 25430771). Also has endonuclease activity toward 5'-flaps (PubMed : 20603015, PubMed : 20603016, PubMed : 24981866).
See full target information FAN1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of cell biology 219: PubMed31881080

2019

Aurora A promotes chromosome congression by activating the condensin-dependent pool of KIF4A.

Applications

Unspecified application

Species

Unspecified reactive species

Elena Poser,Renaud Caous,Ulrike Gruneberg,Francis A Barr
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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