AB235300

Anti-FAPP2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal FAPP2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human PLEKHA8 aa 1-300.

대체 명칭 보기

FAPP2, PLEKHA8, Pleckstrin homology domain-containing family A member 8, PH domain-containing family A member 8, Phosphatidylinositol-four-phosphate adapter protein 2, Serologically defined breast cancer antigen NY-BR-86, FAPP-2, Phosphoinositol 4-phosphate adapter protein 2, hFAPP2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAPP2 antibody (AB235300)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAPP2 antibody (AB235300)

Paraffin-embedded human kidney tissue stained for FAPP2 using ab235300 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAPP2 antibody (AB235300)

Paraffin-embedded human placenta tissue stained for FAPP2 using ab235300 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human PLEKHA8 aa 1-300. The exact immunogen used to generate this antibody is proprietary information.

Q96JA3

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FAPP2 also known as Four-phosphate adaptor protein 2 is an important protein involved in lipid binding and transport. It has a molecular mass of approximately 56 kDa. This protein predominantly localizes in the Golgi apparatus within cells. Its presence is especially prominent in tissues with high levels of secretory activity. FAPP2 functions through its PtdIns(4)P binding capability which facilitates its role in the secretory pathway allowing the transport of glucosylceramide.

Biological function summary

The actions of FAPP2 include the facilitation of lipid transfer and membrane trafficking. It interacts with specific membrane lipids aiding in the formation of transport carriers essential for lipid delivery and glycosphingolipid synthesis. FAPP2 operates within a complex network involving other proteins to ensure accurate lipid sorting and delivery. Its precise role in orchestrating these cellular activities highlights its significance in maintaining membrane composition and signaling.

Pathways

FAPP2 integrates within critical lipid-related processes including the glycosphingolipid biosynthesis and Golgi membrane trafficking pathways. In the glycosphingolipid biosynthesis FAPP2 connects with glucosylceramide and other lipids orchestrating their transport to appropriate cellular destinations. Additionally FAPP2 shares interactions with proteins like CERT and OSBP which are involved in lipid homeostasis and intracellular transport cementing its place as a mediator of critical lipid dynamics.

FAPP2 has associations with disorders related to lipid metabolism such as Gaucher's disease and other lysosomal storage disorders. In these disorders anomalies in lipid transport and metabolism can exacerbate symptoms due to dysfunctional glycosphingolipid synthesis pathways. FAPP2's interactions with proteins like glucosylceramide synthase further illustrate its involvement in disease mechanisms providing a potential target for therapeutic interventions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Cargo transport protein that is required for apical transport from the Golgi complex. Transports AQP2 from the trans-Golgi network (TGN) to sites of AQP2 phosphorylation. Mediates the non-vesicular transport of glucosylceramide (GlcCer) from the trans-Golgi network (TGN) to the plasma membrane and plays a pivotal role in the synthesis of complex glycosphingolipids. Binding of both phosphatidylinositol 4-phosphate (PIP) and ARF1 are essential for the GlcCer transfer ability. Also required for primary cilium formation, possibly by being involved in the transport of raft lipids to the apical membrane, and for membrane tubulation.

See full target information PLEKHA8

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell cycle (Georgetown, Tex.) 22:1807-1826 PubMed37587724

2023

Downregulation of cancer-associated fibroblast exosome-derived miR-29b-1-5p restrains vasculogenic mimicry and apoptosis while accelerating migration and invasion of gastric cancer cells via immunoglobulin domain-containing 1/zonula occluden-1 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Chenqu Wu,Deming Li,Xun Cheng,Hao Gu,Yanqing Qian,Li Feng

Molecular biology of the cell 30:1523-1535 PubMed30943106

2019

Promiscuity of the catalytic Sec7 domain within the guanine nucleotide exchange factor GBF1 in ARF activation, Golgi homeostasis, and effector recruitment.

Applications

Unspecified application

Species

Unspecified reactive species

Jay M Bhatt,William Hancock,Justyna M Meissner,Aneta Kaczmarczyk,Eunjoo Lee,Ekaterina Viktorova,Sasanka Ramanadham,George A Belov,Elizabeth Sztul

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FAPP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAPP2 antibody (AB235300)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAPP2 antibody (AB235300)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise