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AB235113

Anti-FASTKD2 antibody

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Rabbit Polyclonal FASTKD2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FASTKD2 aa 100-250.

대체 명칭 보기

KIAA0971, FASTKD2

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FASTKD2 antibody (AB235113)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FASTKD2 antibody (AB235113)

Paraffin-embedded human spleen tissue stained for FASTKD2 using ab235113 at 1/300 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FASTKD2 antibody (AB235113)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FASTKD2 antibody (AB235113)

Paraffin-embedded human heart tissue stained for FASTKD2 using ab235113 at 1/300 dilution in immunohistochemical analysis.

After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum for 30 minutes at room temperature. Primary antibody (1% BSA) was incubated at 4°C overnight. The primary antibody was detected by a biotinylated secondary antibody and visualized using a HRP conjugated SP system.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human FASTKD2 aa 100-250. The exact immunogen used to generate this antibody is proprietary information.

Q9NYY8

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보완 제품

Primary Antibodies

AB111548

Anti-FASTKD5 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FASTKD5 antibody (AB111548)

  • 0
  • 0
Primary Antibodies

AB97544

Anti-FASTK antibody

Immunocytochemistry/ Immunofluorescence - Anti-FASTK antibody (AB97544)

  • 0
  • 0
Primary Antibodies

AB88975

Anti-OXA1L antibody

  • 0
  • 0
Primary Antibodies

AB205531

Anti-GRSF1 antibody [EPR16678]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GRSF1 antibody [EPR16678] (AB205531)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/300", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FASTKD2 or FAST kinase domains 2 is a protein with a mass of approximately 83 kDa. It primarily localizes in the mitochondria and plays an important role in RNA processing events there. FASTKD2 is ubiquitously expressed with higher levels observed in tissues with high-energy demands such as the brain heart and skeletal muscle. The protein is recognized for its kinase domains which categorically engage in the modulation of RNA.
Biological function summary

FASTKD2 influences mitochondrial RNA metabolism and helps in the processing of various RNA species. It is a part of the FASTK protein family which consists of several members known for regulating RNA function. FASTKD2 does not act alone; it often interacts with other components of the mitochondrial ribonucleoprotein complex. This interaction is fundamental for ensuring that mitochondria maintain energetic efficiency through effective RNA management.

Pathways

Mitochondrial RNA processing and homeostasis tightly involve FASTKD2. It participates in the mitochondrial translation pathway and the assembly of mitochondrial ribosomes. FASTKD2 has associations with other proteins such as FASTKD3 which shares functional similarities and often cooperates in RNA-related activities within the cell. Such interactions highlight its integrated role in maintaining mitochondrial function.

Defects in FASTKD2 can lead to mitochondrial encephalomyopathy and other mitochondrial dysfunction syndromes. The protein's impairment affects neurological development often contributing to severe complications. FASTKD2 has observed linkage with FASTKD5 in related disorders reflecting their interconnected roles in helping maintain mitochondrial genomic integrity. Understanding these pathways may offer insights into potential therapies for such mitochondrial-related diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed : 25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed : 25683715, PubMed : 26370583, PubMed : 27667664). May play a role in mitochondrial apoptosis.
See full target information FASTKD2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biomolecules 14: PubMed38254638

2024

GDF-15 Inhibits ADP-Induced Human Platelet Aggregation through the GFRAL/RET Signaling Complex.

Applications

Unspecified application

Species

Unspecified reactive species

Baikang Xie,Wenjing Tang,Shuang Wen,Fen Chen,Chao Yang,Min Wang,Yong Yang,Wei Liang
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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