Anti-FBXL18 antibody

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Biological function summary

This protein regulates protein homeostasis and cellular processes by controlling the degradation of target proteins. FBXL18 forms a complex with SKP1 CUL1 and RBX1 in the SCF complex which facilitates the ubiquitination process. Through this function FBXL18 plays a role in processes like cell cycle regulation signal transduction and transcriptional regulation influencing key cellular functions.

Pathways

FBXL18 integrates into the Wnt/β-catenin and NF-κB signaling pathways. In the Wnt/β-catenin pathway FBXL18 interacts with β-catenin playing a part in its degradation and therefore influencing cellular decisions regarding proliferation and differentiation. In the context of the NF-κB pathway FBXL18 affects the stability of proteins like IκB which modulates NF-κB transcription factor activity. This connects FBXL18 to proteins such as β-catenin and IκB within these pathways highlighting its influence on these important signaling cascades.