JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB67232

Anti-FBXL20 antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal FBXL20 antibody. Suitable for WB and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human FBXL20.
1 이미지
Western blot - Anti-FBXL20 antibody (AB67232)
  • WB

Unknown

Western blot - Anti-FBXL20 antibody (AB67232)

Lane 1:

Western blot - Anti-FBXL20 antibody (ab67232) at 0.5 µg/mL

Lane 2:

Western blot - Anti-FBXL20 antibody (ab67232) at 1 µg/mL

Lane 1:

A20 (Mouse reticulum sarcoma cell line) whole cell lysate at 15 µg

Lane 2:

A20 cell lysate at 15 µg

Predicted band size: 48 kDa

Observed band size: 44 kDa,48 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Synthetic Peptide within Human FBXL20. The exact immunogen used to generate this antibody is proprietary information.

Q96IG2

style
left-column

보완 제품

Primary Antibodies

AB70484

Anti-LOK antibody

Immunoprecipitation - Anti-LOK antibody (AB70484)

  • 0
  • 0
Primary Antibodies

AB302909

Anti-GPR56 antibody [EPR26546-78]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry - Anti-GPR56 antibody [EPR26546-78] (AB302909)

  • 0
  • 0
Primary Antibodies

AB2386

Anti-Transglutaminase 2 antibody [CUB 7402]

KO Validated

Western blot - Anti-Transglutaminase 2 antibody [CUB 7402] (AB2386)

  • 5
  • 9
Primary Antibodies

AB45142

Anti-SHIP-1 antibody [EP378Y]

20ul selling size|KO Validated|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-SHIP-1 antibody [EP378Y] (AB45142)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-1 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FBXL20 also known as F-box and leucine-rich repeat protein 20 functions as part of the SCF (SKP1-cullin-F-box) ubiquitin ligase complex. This protein weighs approximately 45 kDa and plays an important role in protein degradation by facilitating ubiquitination marking proteins for proteasomal degradation. FBXL20 shows expression in various tissues including the brain and heart suggesting its role in multiple physiological processes.
Biological function summary

The protein helps regulate important cellular processes such as cell cycle control and signal transduction. It acts as part of the larger SCF complex where it recognizes and binds specific phosphorylated substrates. Through these interactions FBXL20 maintains cellular homeostasis by targeting key regulatory proteins for degradation impacting overall cellular function.

Pathways

FBXL20 integrates into the cell cycle and Wnt signaling pathways. In the cell cycle pathway it ensures proper progression through different phases by targeting cyclins for degradation. In the Wnt signaling pathway FBXL20 affects the stability of proteins like β-catenin important for proper signal transmission. It interacts with related proteins such as SKP1 and Cullin-1 within these pathways to execute its functions efficiently.

FBXL20 influences the development of cancer and neurodegenerative diseases. Altered FBXL20 function can disrupt regular protein degradation patterns leading to accumulations that contribute to tumorigenesis or neuronal damage. In cancer its interaction with proteins such as p53 can affect tumor suppression. Similarly in neurodegenerative diseases like Alzheimer's disrupted degradation pathways involving FBXL20 may play a role in disease progression.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Role in neural transmission (By similarity).
See full target information FBXL20

대체 명칭 보기

FBL2, F-box/LRR-repeat protein 20, F-box and leucine-rich repeat protein 20, F-box/LRR-repeat protein 2-like
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of stem cells 18:59-71 PubMed39734065

2024

The Effect of Nerve Growth Factor on Cartilage Fibrosis and Hypertrophy during Chondrogenesis Using Induced Pluripotent Stem Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Se In Jung,Si Hwa Choi,Jang-Woon Kim,Jooyoung Lim,Yeri Alice Rim,Ji Hyeon Ju
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com