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AB217146

Anti-FCGBP antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal Fcgbp antibody. Suitable for IHC-P and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human IgGFc-binding protein aa 450-550 conjugated to Keyhole Limpet Haemocyanin.

대체 명칭 보기

FC(GAMMA)BP, FCGBP_HUMAN, Fc fragment of IgG binding protein, Fcgamma-binding protein antigen, FcgammaBP, Human Fc gamma BP, IgGFc-binding protein

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB217146)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB217146)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded mouse intestine tissue labeling FCGBP with ab217146 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human IgGFc-binding protein aa 450-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6R7

Specificity

There is a chance that this protein will cross-react with Otogelin based on a 61% sequence similarity.

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대체품

Primary Antibodies

AB121202

Anti-FCGBP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121202)

  • 0
  • 1
Primary Antibodies

AB121199

Anti-FCGBP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121199)

  • 0
  • 0

보완 제품

Primary Antibodies

AB78078

Anti-beta III Tubulin antibody [2G10] - Neuronal Marker

BOND RX™ Validated|KO Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody [2G10] - Neuronal Marker (AB78078)

  • 5
  • 40
Primary Antibodies

AB121199

Anti-FCGBP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FCGBP antibody (AB121199)

  • 0
  • 0
Primary Antibodies

AB180851

Anti-CLCA1 antibody [EPR12254-88]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLCA1 antibody [EPR12254-88] (AB180851)

  • 5
  • 3
Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FCGBP also known as IgGFc-binding protein is a large glycoprotein with an approximate mass of 540 kDa. It plays a mechanical role in binding immunoglobulin G Fc fragments which suggests possible involvement in the immune system. Researchers have observed its expression in various mucosal tissues including the intestinal tract and the airway epithelium. There it may interact with mucosal antibodies and contribute to the formation of protective barriers.
Biological function summary

The function of FCGBP involves interactions within the mucosal immune response. It forms complexes with mucins such as MUC2 facilitating the gel-like structure of mucus essential for barrier function. The protein helps in protecting tissues from pathogens and environmental insults through its role in stabilizing the mucus layer. Such interactions highlight its significance in maintaining mucosal immunity and homeostasis especially in environments exposed to external elements.

Pathways

FCGBP is essential in both the innate and adaptive immune pathways. In the mucosal immunity pathway it collaborates with mucins to regulate pathogen access to epithelial surfaces. Additionally its interactions with proteins like IgG provide a link to the immune system's antibody-mediated processes. Through these pathways FCGBP ensures the protection of mucosal surfaces from pathogenic invasion and supports immune surveillance.

FCGBP shows associations with conditions like inflammatory bowel disease (IBD) and cystic fibrosis. In IBD altered mucosal barrier function implicates FCGBP due to its role in mucus integrity. MUC2 abnormalities often accompany these diseases and show how disrupted interactions with FCGBP contribute to mucosal inflammation and barrier dysfunction. In cystic fibrosis faulty mucus barriers highlight the protein's importance in respiratory health connecting it to pulmonary conditions where disrupted mucus properties are common.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information Fcgbp
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Metabolites 15: PubMed39997701

2025

Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239.

Applications

Unspecified application

Species

Unspecified reactive species

Claire Louise Kelly,Martyna Wydrzynska,Marie M Phelan,Sofya Osharovich,Edward J Delikatny,Violaine Sée,Harish Poptani

Oncology letters 22:526 PubMed34055091

2021

Prognostic and immunological roles of Fc fragment of IgG binding protein in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Qunchuan Zhuang,Aling Shen,Liya Liu,Meizhu Wu,Zhiqing Shen,Huixin Liu,Ying Cheng,Xiaoying Lin,Xiangyan Wu,Wei Lin,Jiapeng Li,Yuying Han,Xiaoping Chen,Qi Chen,Jun Peng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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