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AB321968

Anti-FCRL5 antibody [EPR26948-187]

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Anti-FCRL5 antibody [EPR26948-187] is a Rabbit Monoclonal antibody that is used in FCRL5 Flow Cytometry. Suitable for Human samples.

FCRL5 (Fc receptor-like protein 5) is a protein encoded by the FCRL5 gene, also known as CD307. It plays a role in the immune system, particularly in B cell activation and regulation. FCRL5 is associated with diseases such as hairy cell leukemia and lymphoma.
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Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)

Flow cytometric analysis of Daudi (human Burkitt's lymphoma lymphoblast) (Right) / MOLT-4 (human lymphoblastic leukemia T lymphoblast) (Left) cells labelling FCRL5 with ab321968 at 1/50 dilution (1ug) (Red) compared with a Rabbit monoclonal IgG (ab172730) (Black) isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody).

Goat anti-Rabbit IgG (Alexa Fluor® 647 ab150083) at 1/5000 dilution was used as the secondary antibody.

Negative control : MOLT-4 (PMID : 11290337).
Cross-reactivity with FCRL1 but no cross-reactivity with FCRL2 FCRL3 FCRL4 and FCRL6.

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)

Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cell) cells labelling FCRL5 with ab321968 at 1/500 dilution (0.1ug) / Right compared with a Rabbit monoclonal IgG (ab172730) / Left isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody).

Goat Anti-Rabbit IgG (Alexa Fluor® 488 ab150081) at 1/5000 dilution was used as the secondary antibody.

Cells were co-stained with anti human CD3 conjugated to Brilliant Violet 421. Gated on viable Lymphocytes.
Cross-reactivity with FCRL1 but no cross-reactivity with FCRL2 FCRL3 FCRL4 and FCRL6.

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)

Flow cytometric analysis of NAMALWA (human Burkitt's lymphoma B lymphocyte) (Right) / Jurkat (human T cell leukemia T lymphocyte from peripheral blood) (Left) cells labelling FCRL5 with ab321968 at 1/50 dilution (1ug) (Red) compared with a Rabbit monoclonal IgG (ab172730) (Black) isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody).

Goat anti-Rabbit IgG (Alexa Fluor® 647 ab150083) at 1/5000 dilution was used as the secondary antibody.

Negative control : Jurkat (PMID : 24504816).
Cross-reactivity with FCRL1 but no cross-reactivity with FCRL2 FCRL3 FCRL4 and FCRL6.

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FCRL5 antibody [EPR26948-187] (AB321968)

Flow cytometric analysis of Human PBMC (human peripheral blood mononuclear cell) cells labelling FCRL5 with ab321968 at 1/500 dilution (0.1ug) / Right compared with a Rabbit monoclonal IgG (ab172730) / Left isotype control and an unlabelled control (cells without incubation with primary antibody and secondary antibody).

Goat Anti-Rabbit IgG (Alexa Fluor® 488 ab150081) at 1/5000 dilution was used as the secondary antibody.

Cells were co-stained with anti human CD19 conjugated to Alexa Fluor 647. Gated on viable Lymphocytes.
Cross-reactivity with FCRL1 but no cross-reactivity with FCRL2 FCRL3 FCRL4 and FCRL6.

관련 conjugated 항체와 다양한 조성의 항체 (2)

  • Carrier free

    Anti-FCRL5 antibody [EPR26948-187] - BSA and Azide free

  • 578 PE

    PE Anti-FCRL5 antibody [EPR26948-187]

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR26948-187

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB313603

Human FCRL5 ELISA Kit

Sandwich ELISA - Human FCRL5 ELISA Kit (AB313603)

  • 0
  • 0
Primary Antibodies

AB315808

Anti-GPCR GPRC5D antibody [EPR28376-41]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GPCR GPRC5D antibody [EPR28376-41] (AB315808)

  • 0
  • 0
Primary Antibodies

AB131254

Anti-CD27 antibody [EPR8569]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CD27 antibody [EPR8569] (AB131254)

  • 5
  • 2
Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
Primary Antibodies

AB307406

Anti-CD18 antibody [EPR26929-26]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD18 antibody [EPR26929-26] (AB307406)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/50", "FlowCyt-species-notes": "<p></p>" } } }
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제품 세부 정보

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
배송 시 보관 조건
Conditional Ambient
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The FCRL5 also known as CD307 or Fc receptor-like 5 is a protein predominantly expressed on the surface of B cells and plasma cells. This protein weighs approximately 98 kDa. FCRL5 features structural similarities to classical Fc receptors suggesting a role in immune responses. Its expression is tightly regulated throughout B cell development and has been detected in lymphoid tissues with higher levels reported in bone marrow and secondary lymphoid organs.
Biological function summary

FCRL5 modulates the immune system by influencing B cell activation and differentiation. It participates in the formation of immune complexes playing a dual role in both promoting and inhibiting immune responses depending on the surrounding conditions. This regulatory function suggests that FCRL5 can adjust immune system activities to maintain homeostasis. It acts independently and might form complexes with other immune regulatory proteins to fine-tune B cell responses.

Pathways

FCRL5 plays a role in the adaptive immune response and is associated with the B cell receptor (BCR) signaling pathway. It interacts with proteins such as CD19 and CD79 influencing downstream signaling cascades critical for B cell maturation and effector functions. The interaction of FCRL5 with these pathways highlights its importance in modulating signal transduction that leads to cytokine production and antibody generation.

FCRL5 has been implicated in the pathogenesis of autoimmune diseases and certain hematological cancers such as chronic lymphocytic leukemia (CLL). Abnormal expression or mutations of FCRL5 can dysregulate normal B cell function contributing to disease development. In CLL FCRL5 potentially interacts with proteins like leukocyte-associated immunoglobulin-like receptor 1 (LAIR1) influencing cancer cell survival and proliferation making it a target for therapeutic intervention and a potential biomarker for disease progression.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed : 30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity).
See full target information FCRL5

대체 명칭 보기

CD307e, FCRH5, IRTA2, UNQ503/PRO820, FCRL5, Fc receptor-like protein 5, FcR-like protein 5, FcRL5, BXMAS1, Fc receptor homolog 5, Immune receptor translocation-associated protein 2, FcRH5
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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