JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB79573

Anti-FER (phospho Y402) antibody

Be the first to review this product! 리뷰 제출

|

(3 제품이 사용된 논문 )

Rabbit Polyclonal FER phospho Y402 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FER pY402.
2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FER (phospho Y402) antibody (AB79573)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FER (phospho Y402) antibody (AB79573)

ab79573, at a 1/50 dilution, staining FER in paraffin embedded human brain tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunizing peptide.

Western blot - Anti-FER (phospho Y402) antibody (AB79573)
  • WB

Unknown

Western blot - Anti-FER (phospho Y402) antibody (AB79573)

All lanes:

Western blot - Anti-FER (phospho Y402) antibody (ab79573) at 1/500 dilution

Lane 1:

Jurkat cell extracts, starved (24 hours) at 30 µg

Lane 2:

Jurkat cell extracts, starved (24 hours) at 30 µg with immunizing phospho peptide

Predicted band size: 95 kDa

Observed band size: 50 kDa,93 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human FER pY402. The exact immunogen used to generate this antibody is proprietary information.

P16591

style
left-column

대체품

Primary Antibodies

AB191060

Anti-FER antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FER antibody (AB191060)

  • 0
  • 0
Primary Antibodies

AB187685

Anti-FER antibody

Immunoprecipitation - Anti-FER antibody (AB187685)

  • 0
  • 0

보완 제품

Primary Antibodies

AB219649

Anti-Vinculin antibody [EPR20407] - Loading Control

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Vinculin antibody [EPR20407] - Loading Control (AB219649)

  • 0
  • 0
Primary Antibodies

AB8467

Anti-Lipid A antibody [26-5]

  • 1
  • 1
Primary Antibodies

AB232725

Anti-CD98 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD98 antibody (AB232725)

  • 0
  • 0
Primary Antibodies

AB138518

Anti-PCBD1 antibody [EPR9760(B)]

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PCBD1 antibody [EPR9760(B)] (AB138518)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab79573 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific phosphopeptide. The antibody against non phosphopeptide was removed by chromatography using non phosphopeptide corresponding to the phosphorylation site.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
보관 정보
Stable for 12 months at -20°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The FER protein also known as mouse FER or FER-1 functions as a non-receptor tyrosine kinase within the Fes/Fps subfamily. It has a molecular mass of approximately 94 kDa. FER is expressed across various tissues notably in epithelial cells and is also present in hematopoietic and neural cells. Its kinase activity regulates cell signaling affecting processes like cell proliferation differentiation and survival.
Biological function summary

FER acts as a regulator in signaling pathways essential for cellular communication and structure maintenance. FER interacts within cellular complexes modulating the cytoskeleton and intercellular junctions. It influences actin remodeling impacting cell adhesion and motility. FER's involvement in such activities makes it important for maintaining epithelial integrity and cellular response to external stimuli.

Pathways

FER plays a role in the PI3K/Akt pathway and the MAPK/ERK pathway. These pathways are important for cell growth survival and proliferation. FER interacts with other proteins like STAT3 and JAK2 integrating signals that drive these pathways. By modulating key signaling events FER influences cellular functions and responses to environmental changes.

FER associates with cancer and cardiovascular diseases. Aberrant FER expression and activity have been found in various tumors linking it to cancer progression and metastasis. In cardiovascular disease FER's role in regulating endothelial function connects it to vascular abnormalities. Its interaction with proteins like VEGFR further implicates FER in the pathogenesis of these conditions serving as a potential therapeutic target.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this depends on cell type and stimulus.
See full target information FER pY402

대체 명칭 보기

TYK3, FER, Tyrosine-protein kinase Fer, Feline encephalitis virus-related kinase FER, Fujinami poultry sarcoma/Feline sarcoma-related protein Fer, Proto-oncogene c-Fer, Tyrosine kinase 3, p94-Fer
style
left-column

제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of biological chemistry 299:104825 PubMed37196766

2023

Development of the nonreceptor tyrosine kinase FER-targeting PROTACs as a potential strategy for antagonizing ovarian cancer cell motility and invasiveness.

Applications

Unspecified application

Species

Unspecified reactive species

Yanchun Zhang,Xuexue Xiong,Renhong Sun,Xiaotong Zhu,Chen Wang,Biao Jiang,Xiaobao Yang,Dake Li,Gaofeng Fan

Brain pathology (Zurich, Switzerland) 25:24-32 PubMed24725245

2014

Comorbid rat model of ischemia and β-amyloid toxicity: striatal and cortical degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Zareen Amtul,Shawn N Whitehead,Robin J Keeley,John Bechberger,Alicia L Fisher,Robert J McDonald,Christian C Naus,David G Munoz,David F Cechetto

Proceedings of the National Academy of Sciences of 111:1855-60 PubMed24449884

2014

Different modes of endothelial-smooth muscle cell interaction elicit differential β-catenin phosphorylations and endothelial functions.

Applications

Unspecified application

Species

Unspecified reactive species

Shun-Fu Chang,Li-Jing Chen,Pei-Ling Lee,Ding-Yu Lee,Shu Chien,Jeng-Jiann Chiu
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com