AB231956

Anti-FGF12 antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal FGF12 antibody. Suitable for WB, IHC-P and reacts with Mouse, Rat, Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human FGF12.

대체 명칭 보기

FGF12B, FHF1, FGF12, Fibroblast growth factor 12, FGF-12, Fibroblast growth factor homologous factor 1, Myocyte-activating factor, FHF-1

8 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for FGF12 using ab231956 at 20 μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Formalin-fixed, paraffin-embedded human stomach cancer tissue stained for FGF12 using ab231956 at 20 μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Formalin-fixed, paraffin-embedded human kidney tissue stained for FGF12 using ab231956 at 20 μg/mL in immunohistochemical analysis. DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Formalin-fixed, paraffin-embedded human liver tissue stained for FGF12 using ab231956 at 20 μg/mL in immunohistochemical analysis. DAB staining.

Supplier Data

Western blot - Anti-FGF12 antibody (AB231956)

All lanes:

Western blot - Anti-FGF12 antibody (ab231956) at 1 µg/mL

All lanes:

Mouse cerebrum lysate.

Predicted band size: 27 kDa

true

Supplier Data

Western blot - Anti-FGF12 antibody (AB231956)

All lanes:

Western blot - Anti-FGF12 antibody (ab231956) at 1 µg/mL

All lanes:

Rat heart lysate.

Predicted band size: 27 kDa

true

Supplier Data

Western blot - Anti-FGF12 antibody (AB231956)

All lanes:

Western blot - Anti-FGF12 antibody (ab231956) at 1 µg/mL

All lanes:

Rat cerebrum lysate.

Predicted band size: 27 kDa

true

Supplier Data

Western blot - Anti-FGF12 antibody (AB231956)

All lanes:

Western blot - Anti-FGF12 antibody (ab231956) at 1 µg/mL

All lanes:

Recombinant human FGF12 protein.

Predicted band size: 27 kDa

true

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Rat, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human FGF12.

P61328

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

보관 버퍼

pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

FGF12 also known as fibroblast growth factor 12 is a member of the fibroblast growth factor family and has a molecular mass of approximately 28 kDa. FGF12 is expressed in various human tissues notably in the brain and heart where it plays an essential role in cellular processes. Unlike many other FGF family members FGF12 does not have a heparin-binding domain. This distinction affects its interaction with local extracellular matrices and influences how it functions within cells.

Biological function summary

Fibroblast growth factors regulate cell differentiation growth and tissue repair. Though not a typical secreted growth factor FGF12 functions intracellularly where it contributes to neuronal signaling. FGF12 interacts with ion channels and proteins in the central nervous system suggesting its role in modifying electrical signaling pathways. It does not typically form part of a large complex but it associates with proteins that mediate such signaling functions.

Pathways

FGF12 plays a significant role in the intracellular signaling pathways especially those related to neurogenesis and cardiac conduction. In these pathways FGF12 regulates ion channel activity ensuring proper signal propagation. It connects with related pathways of other fibroblast growth factors such as FGF11 sharing key similarities in modulating electrophysiological properties within excitable cells like neurons and cardiomyocytes.

FGF12 has links to cardiac arrhythmias and epilepsy. Alterations in FGF12 expression can disrupt normal cardiac and neural electrical activity hinting at its involvement in these conditions. It interacts with several ion channels such as the sodium channel subunit SCN5A which can result in clinical manifestations when dysregulated. Understanding FGF12's role provides insights into potential therapeutic targets for managing arrhythmias and seizure disorders.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Involved in nervous system development and function. Involved in the positive regulation of voltage-gated sodium channel activity. Promotes neuronal excitability by elevating the voltage dependence of neuronal sodium channel SCN8A fast inactivation.

See full target information FGF12

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 14:24426 PubMed39424871

2024

Machine learning-based model for CD4 conventional T cell genes to predict survival and immune responses in colorectal cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zijing Wang,Zhanyuan Sun,Hengyi Lv,Wenjun Wu,Hai Li,Tao Jiang

Life science alliance 7: PubMed39304345

2024

PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.

Applications

Unspecified application

Species

Unspecified reactive species

Jore Van Wauwe,Alexia Mahy,Sander Craps,Samaneh Ekhteraei-Tousi,Pieter Vrancaert,Hannelore Kemps,Wouter Dheedene,Rosa Doñate Puertas,Sander Trenson,H Llewelyn Roderick,Manu Beerens,Aernout Luttun

Drug development research 85:e22149 PubMed38349269

2024

FGF12 restrains mitochondria-dependent ferroptosis in doxorubicin-induced cardiomyocytes through the activation of FGFR1/AMPK/NRF2 signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ge Tian,Jing Li,Wenjie Wang,Lina Zhou

BioMed research international 2022:9948461 PubMed35860801

2022

Depletion of Fibroblast Growth Factor 12 Restrains the Viability, Stemness, and Motility of Colorectal Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xueyuan Gao,Zuowei Liao,Rukui Su,Dongni Zheng,Guoyuan Huang,Zhong Huang,Xueyuan Cheng

Scientific reports 11:1199 PubMed33441708

2021

High expression of hypoxia inducible factor 1α related with acquired resistant to EGFR tyrosine kinase inhibitors in NSCLC.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Jin,Feihua Huang,Xianrong Xu,Haidong He,Yingqing Zhang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FGF12 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FGF12 antibody (AB231956)

Western blot - Anti-FGF12 antibody (AB231956)

Western blot - Anti-FGF12 antibody (AB231956)

Western blot - Anti-FGF12 antibody (AB231956)

Western blot - Anti-FGF12 antibody (AB231956)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise