AB51217

Anti-Filamin A antibody

Name: Anti-Filamin A antibody
Brand: Abcam Limited
SKU: AB51217
Rating: 4 (8 reviews)

(8 리뷰들)

(16 제품이 사용된 논문 )

Rabbit Polyclonal Filamin A antibody. Suitable for WB and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human FLNA.

1 이미지

Unknown

Western blot - Anti-Filamin A antibody (AB51217)

All lanes:

Western blot - Anti-Filamin A antibody (ab51217) at 1/300 dilution

Lane 1:

Extracts of 293 cells treated with EGF (200ng/ml, 5mins).

Lane 2:

Extracts of 293 cells treated with EGF (200ng/ml, 5mins) and peptide.

Predicted band size: 281 kDa

Observed band size: 281 kDa

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Synthetic Peptide within Human FLNA. The exact immunogen used to generate this antibody is proprietary information.

P21333

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300 - 1/1000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed : 25358863).

See full target information FLNA

대체 명칭 보기

FLN, FLN1, FLNA, Filamin-A, FLN-A, Actin-binding protein 280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, ABP-280

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제품이 사용된 논문 (16)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed39164108

2024

Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew S Binder,Iris Escobar,Youfen Xu,Aidan M Sokolov,Longbo Zhang,Angélique Bordey

Journal of cellular and molecular medicine 27:2228-2238 PubMed37415307

2023

Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Guillaume Postic,Jean Solarz,Cécile Loubière,Janany Kandiah,Jaysen Sawmynaden,Frederic Adam,Marie Vilaire,Thibaut Léger,Jean-Michel Camadro,Daniella Balduino Victorino,Marie-Claude Potier,Eric Bun,Gautier Moroy,Alexandre Kauskot,Olivier Christophe,Nathalie Janel

Frontiers in cellular neuroscience 16:859882 PubMed35602553

2022

Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.

Applications

Unspecified application

Species

Unspecified reactive species

Mark A Rudolf,Anna Andreeva,Christina E Kim,Anthony C-J DeNovio,Antoan N Koshar,Wendy Baker,Alexander X Cartagena-Rivera,Jeffrey T Corwin

International journal of molecular sciences 23: PubMed35269714

2022

Quantitative Proteomics Reveals Molecular Network Driving Stromal Cell Differentiation: Implications for Corneal Wound Healing.

Applications

Unspecified application

Species

Unspecified reactive species

Krishnatej Nishtala,Trailokyanath Panigrahi,Rohit Shetty,Dhanananajay Kumar,Pooja Khamar,Rajiv R Mohan,Vrushali Deshpande,Arkasubhra Ghosh

Small (Weinheim an der Bergstrasse, Germany) 16:e2000012 PubMed32239653

2020

Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites.

Applications

Unspecified application

Species

Unspecified reactive species

Jeong-Kee Yoon,Dae-Hyun Kim,Mi-Lan Kang,Hyeon-Ki Jang,Hyun-Ji Park,Jung Bok Lee,Se Won Yi,Hye-Seon Kim,Sewoom Baek,Dan Bi Park,Jin You,Seong-Deok Lee,Yoshitaka Sei,Song Ih Ahn,Young Min Shin,Chang Soo Kim,Sangsu Bae,YongTae Kim,Hak-Joon Sung

Oncology reports 41:3424-3434 PubMed31002357

2019

Overexpression of calpain‑1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA.

Applications

Unspecified application

Species

Unspecified reactive species

Changzhao Xu,Xiaoxiao Yu,Yuesheng Zhu,Zhenzhai Cai,Lingmin Yu,Ying Lin,Hejie Yu,Zhanxiong Xue,Lingling Zhou

Integrative biology : quantitative biosciences from nano to macro 8:1049-1058 PubMed27723854

2016

High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew W Holle,Alistair J McIntyre,Jared Kehe,Piyumi Wijesekara,Jennifer L Young,Ludovic G Vincent,Adam J Engler

Neuroscience letters 629:15-18 PubMed27345385

2016

Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels.

Applications

Unspecified application

Species

Unspecified reactive species

Longbo Zhang,Tianxiang Huang,Angélique Bordey

Nature communications 7:11642 PubMed27189435

2016

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3.

Applications

Unspecified application

Species

Unspecified reactive species

Pam Speight,Michael Kofler,Katalin Szászi,András Kapus

ACS nano 9:4435-46 PubMed25768046

2015

Phage-display-guided nanocarrier targeting to atheroprone vasculature.

Applications

Unspecified application

Species

Unspecified reactive species

Lucas H Hofmeister,Sue Hyun Lee,Allison E Norlander,Kim Ramil C Montaniel,Wei Chen,David G Harrison,Hak-Joon Sung

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Filamin A antibody

Western blot - Anti-Filamin A antibody (AB51217)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (16)

Product promise