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AB25673

FITC Anti-CD24 antibody [30-F1]

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Anti-CD24 antibody [30-F1] conjugated to FITC - suitable for flow cytometry, and reacts with mouse samples. Clone [30-F1] is a rat monoclonal antibody cited in 32 publications.

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Flow Cytometry - FITC Anti-CD24 antibody [30-F1] (AB25673)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD24 antibody [30-F1] (AB25673)

C57BL/6 mouse splenocytes were costained using CD24-FITC and CD19-PE to distinguish cell subpopulations. Cells were incubated with Anti-CD24 antibody [30-F1] (FITC) (ab25673) at 1 μg/106 cells.

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

30-F1

Isotype

IgG2c

Light chain 타입

kappa

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Mouse

Applications

Flow Cyt

applications

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대체품

Primary Antibodies

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FITC Anti-CD24 antibody [SN3]

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

  • 5
  • 1
Primary Antibodies

AB134375

Anti-CD24 antibody [SN3]

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

  • 5
  • 1
Primary Antibodies

AB179821

Anti-CD24 antibody [EPR3006(N)]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-CD24 antibody [EPR3006(N)] (AB179821)

  • 0
  • 0
Primary Antibodies

AB228455

Anti-CD24 antibody [EPR19925] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD24 antibody [EPR19925] - BSA and Azide free (AB228455)

  • 1
  • 1
Primary Antibodies

AB202073

Anti-CD24 antibody [EPR19925]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-CD24 antibody [EPR19925] (AB202073)

  • 4
  • 3

보완 제품

Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB237365

Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769]

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Alexa Fluor® 647 Anti-CD8 alpha antibody [EPR21769] (AB237365)

  • 0
  • 0
Primary Antibodies

AB252149

Alexa Fluor® 488 Anti-CD4 antibody [EPR20122]

RabMAb|Recombinant

Flow Cytometry - Alexa Fluor® 488 Anti-CD4 antibody [EPR20122] (AB252149)

  • 0
  • 0
Primary Antibodies

AB313900

Alexa Fluor® 488 Anti-CD11c antibody [KB90]

Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 488 Anti-CD11c antibody [KB90] (AB313900)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
보관 버퍼
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
보관 정보
Store in the dark
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.
Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses (By similarity). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90 (PubMed : 19264983). Plays a role in the control of autoimmunity (PubMed : 20200274).
See full target information Cd24

대체 명칭 보기

CD24, Cd24a, Ly-52, Cd24, Signal transducer CD24, Lymphocyte antigen 52, M1/69-J11D heat stable antigen, Nectadrin, R13-Ag, X62 heat stable antigen, HSA
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록and refine your search

Regenerative biomaterials 10:rbad011 PubMed36852397

2023

Selenium-modified bone cement promotes osteoporotic bone defect repair in ovariectomized rats by restoring GPx1-mediated mitochondrial antioxidant functions.

Applications

Unspecified application

Species

Unspecified reactive species

Quan Zhou,Weikai Chen,Chao Gu,Hao Liu,Xiayu Hu,Lei Deng,Wei He,Yong Xu,Xuesong Zhu,Huilin Yang,Xi Chen,Fan He,Tao Liu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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