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AB53319

FITC Anti-DR5 antibody [DR5-01-1]

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(3 제품이 사용된 논문 )

Anti-DR5 antibody [DR5-01-1] conjugated to FITC - suitable for flow cytometry samples. Clone [DR5-01-1] is a mouse monoclonal antibody cited in 5 publications.

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Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (AB53319)
  • Flow Cyt

Unknown

Flow Cytometry - FITC Anti-DR5 antibody [DR5-01-1] (AB53319)

Flow cytometry analysis (surface staining) of CD262 on CD262-transfectants using ab53319 at 5 μg/ml.

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

DR5-01-1

Isotype

IgG1

Conjugation

FITC

Excitation/Emission

Ex: 495nm, Em: 519nm

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human TNFRSF10B. The exact immunogen used to generate this antibody is proprietary information.

O14763

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대체품

Primary Antibodies

AB8416

Anti-DR5 antibody

Immunocytochemistry - Anti-DR5 antibody (AB8416)

  • 4
  • 5
Primary Antibodies

AB55863

PE Anti-DR5 antibody [DR5-01-1]

Flow Cytometry - PE Anti-DR5 antibody [DR5-01-1] (AB55863)

  • 0
  • 0
Primary Antibodies

AB199357

Anti-DR5 antibody [EPR19310]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-DR5 antibody [EPR19310] (AB199357)

  • 5
  • 5
Primary Antibodies

AB230969

Anti-DR5 antibody [EPR22276]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DR5 antibody [EPR22276] (AB230969)

  • 0
  • 0
Primary Antibodies

AB243847

Anti-DR5 antibody [EPR22276] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DR5 antibody [EPR22276] - BSA and Azide free (AB243847)

  • 0
  • 0

보완 제품

Assay Kits

AB46013

Human DR5 ELISA Kit (CD262)

Sandwich ELISA - Human DR5 ELISA Kit (CD262) (AB46013)

  • 0
  • 0
Primary Antibodies

AB59047

FITC Anti-DR4 antibody [DR-4-02]

Flow Cytometry - FITC Anti-DR4 antibody [DR-4-02] (AB59047)

  • 0
  • 0
Primary Antibodies

AB184787

Anti-Caspase-3 antibody [EPR18297]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Caspase-3 antibody [EPR18297] (AB184787)

  • 3
  • 3
Primary Antibodies

AB183474

PE Anti-TRAIL antibody [2E5]

  • 0
  • 0
Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAPDH antibody [EPR16891] - Loading Control (AB181602)

  • 5
  • 23
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" }, "Recombinant full length protein - Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-5 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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제품 세부 정보

The reagent is free of unconjugated FITC.
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 0.2% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

DR5 also known as Death Receptor 5 TRAIL-R2 or TNFRSF10B is a protein critical in apoptosis. It is a transmembrane receptor with a mass of approximately 54 kDa. Researchers find it expressed mostly in tissues such as lung colon and prostate. DR5 functions by binding to its ligand TRAIL triggering the extrinsic apoptotic pathway. Through this mechanism DR5 initiates a cascade of caspase activation that leads to cell death.
Biological function summary

DR5 plays a significant role in the regulation of apoptosis particularly in cancer cells. It is a component of the TRAIL receptor complex which includes several other death receptors like DR4. This complex formation allows DR5 to mediate apoptotic signals more efficiently. By controlling apoptosis DR5 helps maintain tissue homeostasis and prevents abnormal cell proliferation.

Pathways

DR5 is an important part of the TRAIL signaling pathway and the extrinsic apoptosis pathway. It connects with proteins like FADD and Caspase-8 essential in the apoptotic signaling cascade. By interacting with these proteins DR5 drives the progression of the apoptotic signal ensuring the removal of dysfunctional cells. Such pathways are vital for restraining tumor development and progression.

DR5 exhibits significant relevance to cancer and autoimmune diseases. Its ability to induce apoptosis through the TRAIL pathway keeps oncogenic transformations in check. In cancer DR5 often interfaces with other proteins like Bcl-2 which are involved in cell survival. Furthermore defects or aberrant expressions in DR5 have associations with autoimmune disorders where excessive cell death or survival contributes to disease pathology. DR5's role in these conditions makes it a promising target in therapeutic strategies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed : 10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
See full target information TNFRSF10B

대체 명칭 보기

CD262, DR5, KILLER, TRAILR2, TRICK2, ZTNFR9, UNQ160/PRO186, TNFRSF10B, Tumor necrosis factor receptor superfamily member 10B, Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2, TRAIL receptor 2, TRAIL-R2
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in cell and developmental biology 12:1478757 PubMed39568509

2024

Deciphering transcriptome patterns in porcine mesenchymal stem cells promoting phenotypic maintenance and differentiation by key driver genes.

Applications

Unspecified application

Species

Unspecified reactive species

Nadia Khaveh,René Buschow,Julia Metzger

Cell 176:1477-1489.e14 PubMed30827683

2019

Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Liqiang Pan,Tian-Min Fu,Wenbin Zhao,Linlin Zhao,Wen Chen,Chixiao Qiu,Wenhui Liu,Zhijun Liu,Alessandro Piai,Qingshan Fu,Shuqing Chen,Hao Wu,James J Chou

Methods in molecular biology (Clifton, N.J.) 1866:61-73 PubMed30725408

2019

Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction.

Applications

Unspecified application

Species

Unspecified reactive species

Elena Strekalova,Dmitry Malin,Harisha Rajanala,Vincent L Cryns
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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